Determine the role of the SAA-Macrophage Axis on respiratory pathogen clearance in smoke exposure related lung disease.

确定 SAA-巨噬细胞轴对烟雾暴露相关肺部疾病中呼吸道病原体清除的作用。

• 批准号: nhmrc : 1023617
• 负责人: A/Pr Louis Irving
• 金额: $ 41.2万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determine-role-saa-lung-disease/110285
• 关键词: Determine; role; SAA; Macrophage; Axis

Direct or second hand exposure to tobacco smoke significantly increases your risk of acquiring a chest infection. Infants and elderly smokers are particularly susceptible. This will continue to be a major global problem as household smoke exposure remains high in developing countries and disadvantaged indigenous communities. We will investigate how smoke alters important immune cells that normally clear lung infections, which may lead to completely new ways of treating chest infections.

直接或间接接触烟草烟雾会显著增加您获得胸部感染的风险。婴儿和老年吸烟者特别容易受到影响。这将继续是一个重大的全球性问题，因为在发展中国家和处境不利的土著社区，家庭烟雾暴露仍然很高。我们将研究烟雾如何改变通常清除肺部感染的重要免疫细胞，这可能会导致治疗胸部感染的全新方法。