Local SAA production drives glucocortosteriod resistant airway inflammation in COPD

我们最近发现了一种称为SAA的血液标记物，在主要由胸部感染引起的慢性阻塞性肺疾病（COPD）急性发作期间高度升高。这些事件是住院治疗的主要原因。我们以前的研究表明，通过测量血液SAA水平，我们可以通过早期干预来防止病情恶化。我们现在正在探索SAA的生物学作用，以及阻断SAA活性是否会使COPD患者受益。

We have recently identified a blood marker termed SAA that is highly elevated during an acute attack of Chronic Obstructive Pulmonary Disease (COPD) mainly caused by chest infections. These episodes are a major cause of hospitalisation. Our previous studies suggest that by measuring blood SAA levels we can prevent a worsening of the attack with early intervention. We are now exploring the biological role of SAA and whether blocking SAA activity will benefit COPD patients.