Local SAA production drives glucocortosteriod resistant airway inflammation in COPD

本地 SAA 的产生导致 COPD 患者糖皮质激素抵抗性气道炎症

• 批准号: nhmrc : 628511
• 负责人: A/Pr Louis Irving
• 金额: $ 36.05万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/local-saa-production-inflammation-copd/81948
• 关键词: Local; SAA; production; drives; glucocortosteriod

We have recently identified a blood marker termed SAA that is highly elevated during an acute attack of Chronic Obstructive Pulmonary Disease (COPD) mainly caused by chest infections. These episodes are a major cause of hospitalisation. Our previous studies suggest that by measuring blood SAA levels we can prevent a worsening of the attack with early intervention. We are now exploring the biological role of SAA and whether blocking SAA activity will benefit COPD patients.

我们最近发现了一种称为SAA的血液标记物，在主要由胸部感染引起的慢性阻塞性肺疾病（COPD）急性发作期间高度升高。这些事件是住院治疗的主要原因。我们以前的研究表明，通过测量血液SAA水平，我们可以通过早期干预来防止病情恶化。我们现在正在探索SAA的生物学作用，以及阻断SAA活性是否会使COPD患者受益。