Restoring skeletal muscle in an experimental model of COPD by targeting the IGF-1-myostatin-macrophage axis

大多数人认为，慢性阻塞性肺病(肺气肿)患者的严重残疾伴随着肺部的损伤，但肌肉萎缩可能更重要。我们不能再生肺，但我们已经找到了一种方法，可以帮助肌肉再生。我们计划使用干细胞来制造人体自身的一种细胞--巨噬细胞，并对这些细胞进行基因工程，以帮助将修复蛋白直接输送到肌肉中。让肌肉变得更强壮，将有助于COPD患者活得更长，提高生活质量。

Most people think that the serious disabilities of COPD (emphysema) patients follows damage to their lungs but wasted muscles may be even more important. We can not regrow lung but we have found a way that might help regrow muscle. We plan to use stem cells to make one of the body's own cells called 'macrophages' and genetically engineer these cells to help deliver healing proteins directly into the muscle. Making muscle stronger will help COPD patients live longer and improve quality of life.