Restoring skeletal muscle in an experimental model of COPD by targeting the IGF-1-myostatin-macrophage axis

通过靶向 IGF-1-肌生成抑制素-巨噬细胞轴恢复 COPD 实验模型中的骨骼肌

• 批准号: nhmrc : 628492
• 负责人: A/Pr Louis Irving
• 金额: $ 33.89万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/restoring-skeletal-muscle-macrophage-axis/98443
• 关键词: Restoring; skeletal; muscle; experimental; model

Most people think that the serious disabilities of COPD (emphysema) patients follows damage to their lungs but wasted muscles may be even more important. We can not regrow lung but we have found a way that might help regrow muscle. We plan to use stem cells to make one of the body's own cells called 'macrophages' and genetically engineer these cells to help deliver healing proteins directly into the muscle. Making muscle stronger will help COPD patients live longer and improve quality of life.

大多数人认为COPD（肺气肿）患者的严重残疾是由于肺部受损，但肌肉萎缩可能更为重要。我们不能让肺再生，但我们找到了一种帮助肌肉再生的方法。我们计划用干细胞制造一种叫做“巨噬细胞”的人体自身细胞，并对这些细胞进行基因工程改造，以帮助将愈合蛋白直接输送到肌肉中。使肌肉更强壮将有助于慢性阻塞性肺病患者活得更长，提高生活质量。