Controlled release of active compounds from nanocapsule polymers

纳米胶囊聚合物中活性化合物的受控释放

• 批准号: 395373-2009
• 负责人: Tam, KamChiu
• 金额: $ 1.81万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=443619
• 关键词: Controlled; release; active; compounds; nanocapsule

The use of nanocapsules and nanoparticles in the delivery of active compounds (AIs) in agriculture and biomedical applications has been actively pursued. However, the quantification of the release of AIs has been problematic due to the size of these nanoparticles. In order to measure the concentration of AI released from the nanoparticles, the AI loaded nanoparticles have to be separated from the bulk solution. Two common techniques are used, namely centrifugation and filtration, but they present numerous problems, such as forced release of AI, adsorption on filters, and blockage of pores. Thus, an alternative method that is more reliable and accurate needs to be developed to facilitate such measurements. Recently, Tam and co-workers have demonstrated that the Electromotive Force (EMF) measurements can be readily used to perform such measurements. They have demonstrated that the proposed method is accurate and simple to implement. The

在农业和生物医学应用中，纳米胶囊和纳米颗粒在活性化合物（AI）递送中的使用已经被积极追求。然而，由于这些纳米颗粒的尺寸，AI释放的量化一直存在问题。为了测量从纳米颗粒释放的Al的浓度，必须将负载Al的纳米颗粒与本体溶液分离。使用两种常见的技术，即离心和过滤，但它们存在许多问题，例如AI的强制释放、在过滤器上的吸附和孔的堵塞。因此，需要开发一种更可靠和更准确的替代方法来促进这种测量。最近，Tam和同事已经证明，电动势（EMF）测量可以很容易地用于执行这样的测量。他们已经证明，所提出的方法是准确和简单的实施。的