Using a national level multi-registry analysis to determine whether prescribed anti-platelet therapies post-stroke can modify the risk of cognitive decline or dementia

中风幸存者有患痴呆症的风险。中风后血脑屏障的破坏可能会使血液中的药物进入大脑，这些药物可能会对脑细胞产生毒性。氯吡格雷是中风后常用的药物，它阻断了大脑修复所必需的一种受体。中风后，氯吡格雷可能会进入大脑，影响修复过程，增加患痴呆症的风险。我们将使用瑞典国家卫生登记处的数据，将氯吡格雷的使用与中风后痴呆的风险联系起来。

Stroke survivors are at risk of dementia. Blood brain barrier damage after stroke may allow drugs in the bloodstream, which can be toxic to brain cells, to enter the brain. Clopidogrel, a drug commonly used after stroke, blocks a receptor essential for brain repair. After stroke, clopidogrel may access the brain and compromise repair processes, increasing the risk of dementia. We will link use of clopidogrel to the risk of dementia after stroke, using national Swedish health registry data.