Linking Impulsivity Domains and Subjective Response to Alcohol in Young Adults Using Lab and Daily Assessment Methods

使用实验室和日常评估方法将年轻人的冲动域和对酒精的主观反应联系起来

• 批准号: 10453125
• 负责人: ROBERT F LEEMAN
• 金额: $ 68.66万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10453125
• 关键词: Accounting; Address; Alcohol consumption; Alcohols; Area; Biological; Biological Markers; Biosensor; Blood alcohol level measurement; Data; Ecological momentary assessment; Etiology; Event; Exanthema; Expectancy; Failure; Female; Impulsivity; Individual Differences; Intervention; Intravenous; Knowledge; Learning; Link; Measures; Mediating; Mediator of activation protein; Methods; Mission; Modeling; National Institute on Alcohol Abuse and Alcoholism; Outcome; Participant; Patient Self-Report; Persons; Population Intervention; Prevention; Prevention Research; Public Health; Publishing; Research; Rewards; Risk; Risk Factors; Role; Sedation procedure; Self Administration; Sex Differences; Testing; Time; Woman; Wrist; addiction; adolescent alcohol misuse; age group; alcohol consequences; alcohol effect; alcohol measurement; alcohol misuse; alcohol pharmacology; alcohol response; alcohol reward; alcohol sensitivity; alcohol use disorder; base; design; discounting; drinking; high risk; innovation; lectures; men; negative affect; novel; preference; protective factors; response; theories; trait; treatment research; young adult; young woman

PROJECT SUMMARY/ABSTRACT Young adult alcohol misuse is an urgent, growing public health crisis, as young adults have the highest alcohol use disorder rates of any age group with rates increasing in young women. Interventions for this population are hampered by small effects, few options and lack of tailoring to salient risk factors. A recent review in Addiction argued that research informing interventions fails to account for the complexity of relationships among factors contributing to young adult alcohol misuse. We will address these needs by examining relationships between two cardinal etiologic risk factors: impulsivity and subjective response to alcohol (SR). Despite theoretical and biological links between them, little is known about relations between the two risk factors, or how associations between them may promote young adult alcohol misuse longitudinally and on a momentary or daily basis. Prior theory and evidence linking impulsivity and positive, rewarding alcohol effects have been primarily learning and expectancy based. Here, based on exciting preliminary results, we posit an inherent, biological link between impulsivity and high-risk SR (elevated stimulation and dampened sedation). This research is nascent with multiple gaps in knowledge. We will address these gaps by examining impulsivity pre-drinking, SR and alcohol use in a lab setting and via seven 10-day daily assessment periods over 2 years using ecological momentary assessment (EMA) (N=250, 50% female). Using self-report and both lab and mobile tasks, we will characterize 3 unique, established impulsivity domains: poor inhibitory control, delay discounting and negative urgency. SR will be assessed at successive breath alcohol levels using precision intravenous (IV) methods in the lab, followed by opportunity to self-administer more IV alcohol. We will also measure SR at roughly comparable, estimated blood alcohol levels via daily EMA methods. This design enables testing of SR early in a drinking event as a predictor of in-lab and daily alcohol use, along with alcohol use and consequences over time, plus SR’s potential role as a mediator of impulsivity/alcohol relations. Recent findings indicate daily changes in impulsivity predict subsequent drinking and consequences. These types of changes are challenging to capture with lab methods only. Daily measures also enable modeling of both person-level individual differences and daily, within-subject effects. However, there are no published studies relating daily impulsivity and SR measures. In this study, we will: 1) determine relations between lab-based impulsivity and SR; 2) determine relations between daily impulsivity and SR; and 3) relate impulsivity and SR to alcohol misuse longitudinally. We hypothesize impulsivity will relate to heightened stimulation and less sedation following alcohol and that SR will partially mediate relations between impulsivity and alcohol misuse. Evidence of links between specific impulsivity domains and SR longitudinally and on a momentary/daily basis will point to specific intervention targets to ameliorate two critical vulnerability factors for young adult alcohol misuse. Thus, we will: 1) identify mechanisms of alcohol action and 2) facilitate prevention and treatment research: two NIAAA priority areas.

项目摘要/摘要 年轻的成人酒精滥用是一种紧迫的公共卫生危机，因为年轻人的酒精含量最高 年龄段的任何年龄段的疾病率随着年轻女性的增加而增加。该人群的干预措施是 受到小效果的阻碍，几乎没有选择，并且缺乏针对显着危险因素的裁缝。最近的成瘾评论 认为通知干预措施的研究无法解释因素之间关系的复杂性 导致年轻的成人酒精滥用。我们将通过研究 两个基本的病因学风险因素：冲动性和对酒精（SR）的主观反应。尽管有理论和 它们之间的生物学联系，对两个危险因素之间的关系知之甚少，或 他们之间可能会纵向或每天纵向促进年轻的成人酒精滥用。事先的 将冲动性和积极，有益的酒精影响联系起来的理论和证据一直是基本学习和 基于期望。在这里，基于令人兴奋的初步结果，我们在 冲动性和高风险SR（刺激和该死的镇静）。这项研究很新生 知识中的多个差距。我们将通过检查冲动性预先饮用，SR和酒精来解决这些差距 在实验室环境中使用，并在2年内通过七个10天的每日评估期使用生态瞬间 评估（EMA）（n = 250，50％女性）。使用自我报告以及实验室和移动任务，我们将表征 3独特的，已建立的冲动域：抑制性较差，延迟折现和负面急切。 Sr 将使用实验室中的精确静脉（IV）方法在成功的呼气酒精水平上进行评估， 然后有机会自我管理更多的静脉酒精。我们还将在大致可比的情况下测量SR 通过每日EMA方法估计血液酒精水平。该设计使饮酒早期可以测试SR 事件作为利用和日常饮酒的预测因素，以及随着时间的推移的饮酒和后果，加上 SR作为冲动/酒精关系中介的潜在作用。最近的发现表明每天的变化 冲动性预测随后的饮酒和后果。这些类型的变化是捕获的挑战 仅使用实验室方法。每日措施还可以对两个人级的个体差异进行建模和 每天，受试者内部效果。但是，没有关于每日冲动和SR的公开研究 措施。在这项研究中，我们将：1）确定基于实验室的冲动与SR之间的关系； 2）确定 日常冲动与SR之间的关系； 3）纵向滥用酒精的关系冲动和SR。 我们假设冲动性将与酒精后的刺激增强和镇静有关，并且SR 将在冲动和滥用酒精之间部分媒体关系。特定之间联系的证据 冲动性域和SR纵向，每天/每天都会指出特定干预措施 针对年轻成人酒精滥用的两个​​关键脆弱因素的目标。那我们将：1）确定 酒精作用的机制和2）促进预防和治疗研究：两个NIAAA优先区域。