Studies in nanoscale interface and materials science

纳米界面与材料科学研究

• 批准号: 699-2009
• 负责人: Norton, Peter
• 金额: $ 6.56万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=449155
• 关键词: Studies; nanoscale; interface; materials; science

The proposal describes a broad program of nanoscale surface, interface and materials science with emphasis: i) on the coupling of quantitative mechanical and chemical properties at nanometer (nm) length scales in tribology and in soft and hard materials; ii) on the development of new methods of manipulating live cells and studying them with high temporal, spatial (10s of nm) and spectroscopic resolutions at sensitivities approaching single molecule detection, and iii) the study of the dynamics of the formation of water on metal surfaces. The nanotribology studies are focused on understanding the basic mechanisms of friction, lubrication and wear, and involve synchrotron-based XANES imaging, imaging nanoindation, and, most recently, unique new methods of measuring wear at the nm/hr rate. The nanoscale biology work involves creation of patterned, optically transparent substrates contained within microfluidic channels in which labeled live cells can be temporarily immobilized/patterned for study by confocal and near field optical techniques after chosen chemical and physical perturbations, before release and replacement. The Discovery Grant component of my research program will therefore support research in several main areas: 1) the study of ultralow wear-rates of materials; study of the temperature dependence of mechanical properties of materials and antiwear films (nanoscale creep); development of much more sensitive (~ 10 pN) (force compensated probes for materials research using interferometric detection methods; 2) the development and application of the new force-compensated probes for force measurements and for use as platforms for optical and other probes for the study of trafficking of molecules at the membranes of live cells (single molecule; < 10exp-18 L volume sampling); patterning of surfaces within microfluidic channels for biocompatibility and bioactivity; 3) joint developments with Hepburn at UBC of techniques to probe the internal energy state of water produced by the reaction of hydrogen and oxygen on platinum surfaces.

该建议描述了纳米尺度表面、界面和材料科学的广泛计划，重点是：i)摩擦学和软硬材料中纳米(Nm)长度尺度的定量机械和化学性质的耦合；ii)开发操纵活细胞的新方法，并在接近单分子检测的灵敏度下以高时间、空间(10s Nm)和光谱分辨率研究它们；以及iii)研究金属表面形成水的动力学。纳米摩擦学研究的重点是了解摩擦、润滑和磨损的基本机制，涉及基于同步加速器的XANES成像、成像纳米刻度，以及最近以纳米/小时速率测量磨损的独特新方法。纳米尺度的生物学工作包括创建包含在微流控通道中的图案化、光学透明的底物，其中标记的活细胞可以在选择的化学和物理扰动之后、在释放和替换之前被临时固定/图案化，以便通过共聚焦和近场光学技术进行研究。因此，我的研究计划中的发现资助部分将支持几个主要领域的研究：1)材料超低磨损率的研究；材料机械性能与温度的关系的研究和抗磨膜(纳米级蠕变)的研究；更灵敏的(~10Pn)(使用干涉检测方法进行材料研究的力补偿探头)的开发和应用；2)新的力补偿探头的开发和应用，用于力测量，并用作研究活细胞膜上分子运输的光学和其他探头的平台(单分子；和lt；10exp-18 L体积采样)；微流体通道内的表面图案化以实现生物兼容性和生物活性；3)与加州大学赫本分校的赫本共同开发技术，以探测铂表面上氢和氧反应产生的水的内部能量状态。