Development, characterization, and application of new analytical methodologies based on optical and mass spetrometry

我们的团队正在研究和开发大气压电离（API）源，用于连接液相色谱（LC）和质谱（MS）。为了扩大适用于LC-MS的化合物的范围，以及提高LC-MS方法的灵敏度，最近开发了一种新的电离方法，大气压光电离（APPI）。我们正在进行的研究项目之一是旨在阐明负责的APPI源的性能的基本机制，通过电离区域的物理和气相化学的系统研究，将APPI置于坚实的理论基础上。未来的研究项目将进行调查改进的APPI源，以及开发新的API源增强。

Our group is studying and developing atmospheric pressure ionization (API) sources for interfacing liquid chromatography (LC) with mass spectrometry (MS). In an effort to expand the range of compounds amenable to LC-MS, as well as to improve the sensitivity of LC-MS methods in general, a new ionization method, atmospheric pressure photoionization (APPI), has been recently developed. One of our ongoing research projects is aimed at elucidating the fundamental mechanisms responsible for the performance of the APPI source, to place APPI on a firm theoretical foundation through a systematic study of the photophysics and gas-phase chemistry in the ionization region. Future research projects will be undertaken to investigate improvements to the APPI source, as well as to develop novel API source enhancements.