Development, characterization, and application of new analytical methodologies based on optical and mass spetrometry

我们的小组正在研究和开发用于连接液相色谱 (LC) 和质谱 (MS) 的大气压电离 (API) 源。为了扩大适用于 LC-MS 的化合物范围，并提高 LC-MS 方法的总体灵敏度，最近开发了一种新的电离方法，即大气压光电离 (APPI)。我们正在进行的研究项目之一旨在阐明影响 APPI 源性能的基本机制，通过对电离区域光物理和气相化学的系统研究，为 APPI 奠定坚实的理论基础。未来的研究项目将调查对 APPI 源的改进，以及开发新颖的 API 源增强功能。

Our group is studying and developing atmospheric pressure ionization (API) sources for interfacing liquid chromatography (LC) with mass spectrometry (MS). In an effort to expand the range of compounds amenable to LC-MS, as well as to improve the sensitivity of LC-MS methods in general, a new ionization method, atmospheric pressure photoionization (APPI), has been recently developed. One of our ongoing research projects is aimed at elucidating the fundamental mechanisms responsible for the performance of the APPI source, to place APPI on a firm theoretical foundation through a systematic study of the photophysics and gas-phase chemistry in the ionization region. Future research projects will be undertaken to investigate improvements to the APPI source, as well as to develop novel API source enhancements.