Development, characterization, and application of new analytical methodologies based on optical and mass spetrometry

基于光学和质谱的新分析方法的开发、表征和应用

• 批准号: 1525-2007
• 负责人: Blades, Michael
• 金额: $ 5.46万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=449283
• 关键词: Development; characterization; application; new; analytical

Our group is studying and developing atmospheric pressure ionization (API) sources for interfacing liquid chromatography (LC) with mass spectrometry (MS). In an effort to expand the range of compounds amenable to LC-MS, as well as to improve the sensitivity of LC-MS methods in general, a new ionization method, atmospheric pressure photoionization (APPI), has been recently developed. One of our ongoing research projects is aimed at elucidating the fundamental mechanisms responsible for the performance of the APPI source, to place APPI on a firm theoretical foundation through a systematic study of the photophysics and gas-phase chemistry in the ionization region. Future research projects will be undertaken to investigate improvements to the APPI source, as well as to develop novel API source enhancements.

我们小组正在研究和开发用于液相色谱（LC）和质谱（MS）界面的大气压电离（API）源。为了扩大适用于LC-MS的化合物范围，并提高LC-MS方法的灵敏度，最近发展了一种新的电离方法——大气压光电离（APPI）。我们正在进行的研究项目之一是旨在阐明APPI源性能的基本机制，通过系统地研究电离区域的光物理和气相化学，为APPI奠定坚实的理论基础。未来的研究项目将用于调查APPI源的改进，以及开发新的API源增强功能。