Regulation of glucose uptake in peripheral tissues

外周组织葡萄糖摄取的调节

• 批准号: 41597-2009
• 负责人: Chan, Catherine
• 金额: $ 1.46万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=450802
• 关键词: Regulation; glucose; uptake; peripheral; tissues

Maintaining blood sugar levels within normal limits is essential to an animal's well-being because the brain needs a constant supply of sugar. The main blood sugar, glucose, stimulates insulin secretion, which then leads to uptake and metabolism of glucose by tissues such as muscle, liver and fat. When insulin binds to muscle or liver cells, it initiates a cascade of enzymatic reactions that eventually lead to increased glucose metabolism. The factors that regulate this cascade is not completely known. One theory is that the cell's ability to make energy (called ATP) changes under certain nutritional conditions, and that low cellular ATP impairs the ability of the cells to take up and use glucose. In this project, we will investigate the role of ATP in determining

将血糖水平保持在正常范围内对动物的健康至关重要，因为大脑需要持续的糖供应。主要的血糖，葡萄糖，刺激胰岛素的分泌，然后导致肌肉，肝脏和脂肪等组织对葡萄糖的吸收和代谢。当胰岛素与肌肉或肝脏细胞结合时，它会启动一连串的酶反应，最终导致葡萄糖代谢增加。调节这种级联反应的因素并不完全清楚。一种理论认为，在特定的营养条件下，细胞产生能量(称为ATP)的能力会发生变化，而细胞内较低的ATP会削弱细胞吸收和利用葡萄糖的能力。在这个项目中，我们将研究ATP在决定