The design, synthesis and use of chiral ligands in various organic reactions: applications toward the asymmetric synthesis of natural products

该提案的目标是在某些关键步骤中设计、制备和使用新的手性配体和手性刘易斯酸，以不对称合成表现出感兴趣的生物活性（抗癌特性等）的天然产物。 这些新的手性实体与金属（Pd、Rh、Ru等）结合使用。和刘易斯酸（Al）在反应中优先形成一种对映体超过另一种对映体。 其他正在研究的不对称反应包括分子内和分子间的Diels桤木反应、金属催化的阴离子捕获反应和铑催化的氢化反应。 这些反应的机理使用同位素、各种NMR技术和/或理论计算（半经验和DFT）来研究。 我们还在高压下和/或使用微波进行一些这些不对称反应。

The goal of this proposal is to design, prepare and use new chiral ligands and chiral Lewis acids within certain key steps towards the asymmetric synthesis of natural products exhibiting interesting biological activity (anticancer properties, etc.). These new chiral entities are used in conjunction with metals (Pd, Rh, Ru, etc.) and Lewis acids (Al) in reactions that preferentially form one enantiomer in excess over the other. Other asymmetric reactions being studied include intra- and inter-molecular Diels Alder reactions, metal-catalyzed anion capture reactions and rhodium-catalyzed hydrogenations. The mechanism(s) of these reactions are studied using isotopes, a variety of NMR techniques and/or theoretical calculations (semi-empirical and DFT). We also execute some of these asymmetric reactions under high pressures and/or using microwaves.