Viral and host factors determining outcome of Zika virus infection

决定寨卡病毒感染结果的病毒和宿主因素

• 批准号: nhmrc : GNT1144950
• 负责人: A/Pr Gregor Devine
• 金额: $ 91.08万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/viral-host-factors-virus-infection/1348649
• 关键词: Viral; host; factors; determining; outcome

The proposal aims at identifying viral and host factors determining outcomes of infection with Zika virus, a significant mosquito-transmitted pathogen associated with debilitating neurological pathology in new-borne babies from mothers infected during pregnancy. We will use cutting edge methodologies and infections models to bring our understanding of Zika virus infection to unprecedented level. The results could also facilitate identification of targets for effective anti-viral therapy.

该提案旨在确定决定寨卡病毒感染结果的病毒和宿主因素，寨卡病毒是一种重要的蚊子传播病原体，与怀孕期间感染母亲的新生儿的神经病理学衰弱有关。我们将使用最先进的方法和感染模型，使我们对寨卡病毒感染的理解达到前所未有的水平。这些结果也有助于确定有效抗病毒治疗的靶点。