Modulation of DNA repair by cellular deubiquitinases

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Cells in the body are under constant attack from radiation and chemicals (known as "mutagens") in the environment that damage DNA, thus leading to the formation of harmful mutations which alter the genetic code, in turn destroying the function of important proteins. Fortunately our cells possess various "DNA repair pathways" that can remove segments of damaged DNA before these segments can be converted into mutations. As such, the major goal of my laboratory has been to better understand the mechanisms surrounding how human cells repair their DNA.