Modulation of DNA repair by cellular deubiquitinases

细胞去泛素酶对 DNA 修复的调节

• 批准号: 155198-2008
• 负责人: Drobetsky, Elliot
• 金额: $ 2.77万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=452006
• 关键词: Modulation; DNA; repair; cellular; deubiquitinases

Cells in the body are under constant attack from radiation and chemicals (known as "mutagens") in the environment that damage DNA, thus leading to the formation of harmful mutations which alter the genetic code, in turn destroying the function of important proteins. Fortunately our cells possess various "DNA repair pathways" that can remove segments of damaged DNA before these segments can be converted into mutations. As such, the major goal of my laboratory has been to better understand the mechanisms surrounding how human cells repair their DNA.

人体细胞不断受到辐射和环境中破坏DNA的化学物质（称为“诱变剂”）的攻击，从而导致形成改变遗传密码的有害突变，进而破坏重要蛋白质的功能。幸运的是，我们的细胞拥有各种“DNA修复途径”，可以在受损DNA片段转化为突变之前将其移除。因此，我的实验室的主要目标是更好地理解人类细胞修复DNA的机制。