The role rer/microtubule interaction in the establishment and maintenance of neuronal polarity

rer/微管相互作用在神经元极性建立和维持中的作用

• 批准号: 197257-2007
• 负责人: Leclerc, Nicole
• 金额: $ 2.55万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=452799
• 关键词: role; rer; microtubule; interaction; establishment

The brain cells called neurons extend two types of long processes, dendrites and axon. The dendrites are the receptive compartment where communication between neurons occurs through a specialized structure, the synapse. The axon is the transmitter compartment that propagates electrical impulses to other neurons. Neurons undergo dendritic and axonal morphological changes during memory, learning and adaptation. These changes involves two phenomena : 1- a reorganization of the architectural elements of the neuron called the cytoskeleton 2- membrane supply to the new processes. Our research aims to understand the molecular events that coordinate these two phenomena. In particular, we investigate the role of the cytoskeletal element called microtubules in the morphological changes of a neuron. Our reseach should lead to a better comprehension of the molecular mechanisms underlying memory, learning and adaptation.

被称为神经元的脑细胞延伸出两种类型的长过程，树突和轴突。树突是接受区室，神经元之间的通信通过一个专门的结构，突触发生。轴突是将电脉冲传播到其他神经元的递质室。神经元在记忆、学习和适应过程中经历树突和轴突形态学变化。这些变化涉及两种现象：1-称为细胞骨架的神经元结构元件的重组2-新过程的膜供应。我们的研究旨在了解协调这两种现象的分子事件。特别是，我们调查的细胞骨架元件称为微管在神经元的形态变化的作用。我们的研究将有助于更好地理解记忆、学习和适应的分子机制。