The role rer/microtubule interaction in the establishment and maintenance of neuronal polarity

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The brain cells called neurons extend two types of long processes, dendrites and axon. The dendrites are the receptive compartment where communication between neurons occurs through a specialized structure, the synapse. The axon is the transmitter compartment that propagates electrical impulses to other neurons. Neurons undergo dendritic and axonal morphological changes during memory, learning and adaptation. These changes involves two phenomena : 1- a reorganization of the architectural elements of the neuron called the cytoskeleton 2- membrane supply to the new processes. Our research aims to understand the molecular events that coordinate these two phenomena. In particular, we investigate the role of the cytoskeletal element called microtubules in the morphological changes of a neuron. Our reseach should lead to a better comprehension of the molecular mechanisms underlying memory, learning and adaptation.