Time varying modulators of spine injury mechanics and material properties of the intervertebral disc

脊柱损伤力学和椎间盘材料特性的时变调制器

• 批准号: 227638-2010
• 负责人: Callaghan, Jack
• 金额: $ 2.33万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=454610
• 关键词: Time; varying; modulators; spine; injury

Globally, the World Health Organization has deemed low back pain one of the top three occupational health problems. Eighty percent of the population will suffer from low back pain at some point in their life making low back pain the most prevalent and costly musculoskeletal problem affecting the general population of Canada. Evidence suggests that the primary cause of low back pain is through mechanical exposure associated with everyday activities and industrial tasks. The overall objective of this research program is to determine the role of daily loading exposures in the generation of low back tissue damage and pain. The causes of injury initiation and progression in the structures of the spine (e.g. the intervertebral disc), associated with repetitive exposure will be investigated. It is critical to develop a solid understanding of the material properties of the intervertebral disc and the injury mechanisms associated with mechanical loading, as the biological repair mechanisms in the intervertebral disc are slow due to the lack of blood supply to this structure. The ability of the spinal tissues to repair themselves can be easily outpaced by injury deterioration once the first stage of an injury to the intervertebral disc has occurred. The outcomes from this research will provide time dependent tissue material properties that are currently unavailable and are a limiting factor in the understanding and modeling of the intervertebral and low back injuries. Ultimately, the linking of cumulative or repetitive exposure to potential pain generation would be a powerful contribution in developing methods to assess daily loading and set threshold limits or exposure standards to prevent injuries.

在全球范围内，世界卫生组织将腰痛视为三大职业健康问题之一。百分之八十的人口将遭受腰痛在某些时候在他们的生活使腰痛最普遍和昂贵的肌肉骨骼问题影响加拿大的一般人口。有证据表明，腰痛的主要原因是通过与日常活动和工业任务相关的机械暴露。这项研究计划的总体目标是确定日常负荷暴露在产生下背部组织损伤和疼痛中的作用。将研究与重复暴露相关的脊柱结构（例如椎间盘）损伤发生和进展的原因。对椎间盘的材料特性和与机械负荷相关的损伤机制有深入的了解是至关重要的，因为椎间盘中的生物修复机制由于缺乏对该结构的血液供应而缓慢。一旦发生椎间盘损伤的第一阶段，脊柱组织的自我修复能力很容易被损伤恶化所超越。本研究的结果将提供目前不可用的时间依赖性组织材料特性，这些特性是椎间和下背部损伤理解和建模的限制因素。最终，累积或重复暴露与潜在疼痛产生的联系将是一个强大的贡献，在开发方法，以评估每日负荷和设置阈值限制或暴露标准，以防止伤害。