Exploiting Zwitterionic late metal complexes in addressing challenging bond activation chemistry

利用两性离子晚金属配合物解决具有挑战性的键活化化学问题

• 批准号: 249580-2009
• 负责人: Stradiotto, Mark
• 金额: $ 3.64万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=455313
• 关键词: Exploiting; Zwitterionic; late; metal; complexes

Chemical research will figure prominently in addressing a number of societal challenges, including: (a) the development of environmentally friendly methods for the conversion of abundant raw materials into value-added products, including pharmaceuticals; (b) the more efficient utilization of our diminishing hydrocarbon resources; and (c) the identification of recyclable materials for the controlled release of combustible molecules such as hydrogen. One difficulty common to these challenges is the selective breaking and reforming unreactive substrate E-H bonds (E = H, C, N, P, etc.). When appropriately constructed, transition metal complexes are able to activate (i.e. induce reactivity in) typically unreactive molecular fragments, including E-H bonds. While significant advances have been made in metal-mediated single E-H bond activation catalysis, related processes involving the activation of two E-H bonds within a substrate (double E-H bond activation) are comparatively few. Given the central role that double E-H bond activation could play in addressing the reactivity challenges outlined above, the design of metal catalysts that can mediated double E-H bond activation reactions represents an important, yet formidable, challenge.

化学研究将在应对若干社会挑战方面发挥重要作用，这些挑战包括：（a）开发无害环境的方法，将丰富的原材料转化为增值产品，包括药品;（B）更有效地利用我们日益减少的碳氢化合物资源;（c）确定可回收材料，以控制释放氢等可燃分子。这些挑战共同的一个困难是选择性断裂和重整非反应性底物E-H键（E = H、C、N、P等）。当适当构造时，过渡金属络合物能够活化（即诱导反应性）通常不反应的分子片段，包括E-H键。虽然在金属介导的单E-H键活化催化中已经取得了显著的进展，但是涉及底物内的两个E-H键的活化（双E-H键活化）的相关过程相对较少。考虑到双E-H键活化在解决上述反应性挑战中可能发挥的核心作用，可以介导双E-H键活化反应的金属催化剂的设计代表了一个重要但艰巨的挑战。