Neuregulins as modulators of dendritic growth and plasticity in the cerebral cortex

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The cerebral cortex is a complex network involved in the high-level treatment of sensory, motor and cognitive information. Efficient processing requires cortical neurons to continuously integrate thousands of intra- and extra-cortical inputs, which are mostly found on dendritic branches and spines. Dendrites are elaborate structures which can be shaped by neuronal activity. Here, we propose to study how growth factors called neuregulins influence the growth of cortical dendrites. This study will contribute to our understanding of the biological mechanisms underlying morphological adaptations of brain circuitries.