Companion protease inhibitors for the protection of clinically-useful recombinant proteins in plants

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Several proteins of medical interest have been produced successfully in « plant protein biofactories » over the last ten years, including a variety of vaccines, diagnostic antibodies, protein allergens and peptidic hormones. The main goal of this project is to develop a plant expression system for the production of medically-useful proteins susceptible to degradation in foreign environments. The general idea is to provide Canadian biotech companies with molecular tools useful in making plant factories a milder environment for fragile proteins. Protein-stabilizing proteins called protease inhibitors will first be designed by current genetic and protein engineering approaches, and then used as 'companion molecules' to protect the proteins of interest in the host plant tissues. This new concept for recombinant protein protection will be tested with several proteins of