Label free high sensitivity detection of bacteria by phages using functionalized optical microcavities

使用功能化光学微腔通过噬菌体对细菌进行无标记高灵敏度检测

• 批准号: 365207-2008
• 负责人: Peter, YvesAlain
• 金额: $ 12.35万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Strategic Projects - Group
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=460931
• 关键词: Label; free; sensitivity; detection; bacteria

This proposal addresses challenges that Canada is facing presently and will face for the next few decades. As seen recently on the international scene, emerging and re-emerging infectious diseases propagated by bacteria might threaten populations' health. To address these issues, Canada will need advanced biomedical technologies for early detection of infectious diseases in humans and animals. Detection of pathogenic bacteria is very important in various sectors like medical diagnosis, nosocomial infections, food safety, and biological war. In order to establish a prevention plan, or an effective intervention plan in the event of bacterial contamination, it is necessary to carry out a significant, specific and fast detection. Current tests require days and even weeks to confirm a diagnosis of the presence of a pathogen and other infectious diseases in a patient. The development of affordable diagnostic technologies, such as Point-of-Care Testing (POTC) devices, in the form of hand-held devices will provide for more timely and accurate test results. POTC is extremely interesting since it can be performed at the site of the patient care, such as in emergency rooms, battlefields, outpatient clinics, nursing homes, patients' homes or hospital bedside, with the result leading to possible change in the care of the patient.

这一建议涉及加拿大目前面临的挑战，并将在未来几十年面临的挑战。正如最近在国际舞台上看到的那样，新出现和重新出现的由细菌传播的传染病可能威胁到人口的健康。为了解决这些问题，加拿大将需要先进的生物医学技术来早期检测人类和动物的传染病。病原菌的检测在医疗诊断、医院感染、食品安全和生物战等各个领域都非常重要。为了建立预防计划，或在发生细菌污染时的有效干预计划，有必要进行显著、特异和快速的检测。目前的测试需要几天甚至几周的时间来确认患者体内病原体和其他传染病的诊断。开发负担得起的诊断技术，如手持设备形式的即时检测（POTC）设备，将提供更及时和准确的检测结果。POTC是非常有趣的，因为它可以在病人护理的现场进行，例如在急诊室，战场，门诊诊所，疗养院，病人的家或医院床边，结果导致病人护理的可能变化。