Genetics and evolution of Shigella O antigens

志贺氏菌 O 抗原的遗传学和进化

• 批准号: ARC : DP0210675
• 负责人: Prof Peter Reeves
• 金额: $ 17.6万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetics-evolution-shigella-o-antigens/62841
• 关键词: Genetics; evolution; Shigella; antigens

Genetics and evolution of Shigella O antigens. We use genome scale sequencing techniques to sequence 26 O-antigen gene clusters from Shigella. With the seven already known, this will give sequences for every O-antigen of Shigella. This will be the first time that such set is fully sequenced. Shigella are human specific pathogens, have emerged with the evolution of humans. O-antigens are important for their life and pathogenicity. This project will greatly extend our knowledge of the genetic basis and evolution of this important polymorphism. O-antigens are used for typing Shigella and also elicit strong immunity. The molecular data will help establish DNA based typing and vaccine development.

志贺氏菌O型抗原的遗传和进化。我们使用基因组级测序技术对志贺氏菌的26个o抗原基因簇进行测序。有了已知的7种，这将得到每个志贺氏菌o型抗原的序列。这将是第一次对这样的集合进行完全测序。志贺氏菌是人类特有的病原体，随着人类的进化而出现。o型抗原对其生命和致病性具有重要意义。这个项目将极大地扩展我们对这种重要多态性的遗传基础和进化的认识。o型抗原用于志贺氏菌分型，也可引起很强的免疫力。分子数据将有助于建立基于DNA的分型和疫苗开发。