Elucidation of bacterial glycosylytransferase specificity

细菌糖基转移酶特异性的阐明

• 批准号: DP0559665
• 负责人: Prof Peter Reeves
• 金额: $ 15.94万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-03-03 至 2008-12-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0559665
• 关键词: Elucidation; bacterial; glycosylytransferase; specificity

The benefits are involvement in the growth area of polysaccharide research, with potential for major industrial spin off. Polysaccharides are critical in all organisms as signalling, structural and storage compounds. Bacteria make a wide variety with extensive use of unusual sugars, some with uses from oil emulsifiers to food thickeners. The project is on the enzymes that assemble bacterial polysaccharides. We are world leaders in genetics of the gene clusters especially synthesis of the unusual sugars. We now aim to fill a major gap by determining which enzymes make which bonds, leading to options for new gene combinations and novel structures. We have a lead in research in this area and Australia gains if we maintain that lead.

其好处是参与了多糖研究的增长领域，有可能成为主要的工业副产品。多糖在所有生物体中作为信号、结构和储存化合物是至关重要的。细菌通过广泛使用不寻常的糖来制造各种各样的糖，其中一些糖的用途从油乳化剂到食品增稠剂。这个项目是关于组装细菌多糖的酶。我们在基因簇的遗传学方面处于世界领先地位，特别是在不寻常的糖的合成方面。我们现在的目标是通过确定哪些酶产生哪些键来填补一个主要的空白，从而为新的基因组合和新的结构提供选择。我们在这一领域的研究处于领先地位，如果我们保持这种领先地位，澳大利亚就会受益。