Synthesis and assembly of bacterial repeat unit polysaccharides

细菌重复单元多糖的合成和组装

• 批准号: DP0452629
• 负责人: Prof Peter Reeves
• 金额: $ 15.67万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-06-01 至 2007-06-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0452629
• 关键词: Synthesis; assembly; bacterial; repeat; unit

Bacteria make an enormous range of surface polysaccharides. The complexity was first appreciated as antigenic diversity, but we now have hundreds of chemical structures and perhaps a hundred sequences of their gene clusters, but the number in nature must be many thousands. Our knowledge of gene function is growing but is not keeping up with the discovery of new sequences and structures. The aim is to determine structure and function of key O antigen processing genes and the functions of a range of glycosyl transferases, and to use the information to generate novel gene clusters to synthesise novel polysaccharides

细菌可以制造大量的表面多糖。这种复杂性最初被认为是抗原的多样性，但我们现在有数百种化学结构，也许有一百个基因簇的序列，但自然界中的数量肯定有数千个。我们对基因功能的了解正在增长，但没有跟上新序列和结构的发现。目的是确定关键O抗原加工基因的结构和功能以及一系列糖基转移酶的功能，并利用这些信息产生新的基因簇来合成新的多糖