Modular confocal laser microscope system

需要资金紧急更换一个共焦荧光显微镜系统，该系统为确定极薄薄膜内的结构和反应动力学提供核心仪器能力。Krull的研究项目主要集中在化学选择性表面的设计，用于开发通过测量荧光强度进行操作的生物传感器和生物测定。这些技术使用直接固定到表面的选择性探针，使得在生物识别事件中靶的结合可以提供局部可测量的分析信号。当与微流体流动控制相结合时，这种技术可以提供出色的选择性，并可以将探针材料完全反应的时间从几小时减少到几分钟。

Funds are requested for the urgent replacement of a confocal fluorescence microscope system that affords a core instrumental capability for determination of the structure and reaction dynamics within very thin films. Krull's research program focuses on the design of chemically-selective surfaces for development of biosensors and bioassays that operate by measuring fluorescence intensity. These technologies use selective probes that are immobilized directly to a surface so that binding of target in a bio-recognition event can provide for a localized measurable analytical signal. When combined with microfluidic flow control, such technology can offer outstanding selectivity, and can reduce the time for complete reaction of the probe material from several hours to several minutes.