Dissecting microscope with imaging capability

包围我们身体每个细胞的膜是重要的屏障，它们的结构在一定程度上取决于它的脂肪成分。对这种结构的改变可以改变细胞的功能。肌肉很重要，因为它是身体中最大的组织，对整体健康起着重要作用。我的研究计划的重点是研究肌膜的脂肪构成如何影响肌膜与邻近细胞结构的联系。在某些与肌肉相关的功能障碍(结构和代谢)中，肌膜膜(外细胞膜)，更具体地说，这一膜的脂肪成分，可能起到作用。为了检查肌膜的脂肪组成，过去的研究依赖于对这些组分的积极提取和分离，质疑它们的纯度和代表性。最新的与肌膜结构无关的方法可能被证明在检查纯膜和代表性膜方面是有用的。分离肌肉细胞膜需要显微解剖和显微操作，并需要专门的显微镜系统。这项研究的结果将帮助我们了解是什么保持肌肉健康，以及饮食中的脂肪如何损害肌肉。

Membranes that surround every cell in our body are important barriers and their structure is dependent, in part, on its fat composition. Changes to this structure can change the function of the cell. Muscle is important because it is the largest tissue in the body and plays a role in overall health. The focus of my research program is to examine how fat makeup of muscle membranes can influence the membranes association with neighbouring cell structures. There are certain muscle related dysfunctions (structural and metabolic) in which the sarcolemmal membrane (outer cell membrane), and more specifically the fat composition of this membrane, may play a role. In an attempt to examine the fat makeup of sarcolemmal membrane, past research has relied on aggressive extraction and isolation of these fractions, questioning their purity and representative nature. Recent methodology unrelated to muscle membrane structure may prove useful in examining pure and representative membranes. Micro-dissection and micro-manipulation is needed to isolate the muscle cell membrane and requires a specialized microscope system. The results of this research will help us understand what keeps muscle healthy and how fats in our diets may harm the muscle.