Influence of nutrition and physical activity on skeletal muscle membrane structure and function

营养和体力活动对骨骼肌膜结构和功能的影响

• 批准号: 327015-2006
• 负责人: LeBlanc, Paul
• 金额: $ 0.98万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=397532
• 关键词: Influence; nutrition; physical; activity; skeletal

Biological membranes that surround every cell in our body are important selectively permeable barriers that carry out many critical cellular processes associated with cell growth, communication, and metabolism.  Membrane structure is dependent, in part, on its fatty acid composition.  Alterations to membrane structure can impact cellular function. The major focus of the proposed research is to examine how membrane structure is influenced with diet (high fat) and exercise (endurance training) by examining the fatty acid composition of specific skeletal muscle organelles.  Specifically, this proposal addressed the significance of different kinds of dietary fats (saturated, monounsaturated, and polyunsaturated fats) and their role in membrane remodelling.  The long-term goals of this research program are to compare and contrast the underlying physiological and metabolic adaptations in healthy mammalian skeletal muscle with nutrition and physical activity and how these adaptations differ under certain metabolic disorders such as obesity and type 2 diabetes.

生物膜包围着我们身体中的每个细胞，是重要的选择性渗透屏障，执行与细胞生长，通讯和代谢相关的许多关键细胞过程。膜结构部分取决于其脂肪酸组成。膜结构的改变可以影响细胞功能。拟议研究的主要重点是研究饮食如何影响膜结构（高脂肪）和运动通过检测特定骨骼肌细胞器的脂肪酸组成来研究耐力训练。具体来说，该建议阐述了不同种类的膳食脂肪的重要性（饱和，单不饱和，和多不饱和脂肪）及其在膜重塑中的作用。这项研究计划的长期目标是比较和对比健康哺乳动物骨骼肌与营养和体力活动的潜在生理和代谢适应，以及这些适应在某些代谢紊乱如肥胖和2型糖尿病下的差异。糖尿病