Infrared spectrometer for real-time, in situ reaction monitoring

用于实时原位反应监测的红外光谱仪

• 批准号: 407766-2011
• 负责人: Taylor, Mark
• 金额: $ 5.45万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=472717
• 关键词: Infrared; spectrometer; real; time; situ

The ability to develop and optimize new chemical processes for application in drug discovery and production, polymer synthesis, and the manufacture of high-value chemicals and materials, requires understanding of reaction mechanism, the detailed sequence of bond-making and bond-breaking events through which a given chemical change occurs. Funding from NSERC will be used to purchase an infrared (IR) spectrometer that enables the real-time, in-line monitoring of novel chemical transformations discovered by our research groups. This instrument will provide a level of insight into the details of reaction pathways that is not available using existing equipment, enabling students and postdoctoral researchers in our groups to develop the next generation of "green", catalytic processes and multicomponent reactions for the preparation of value-added chemical products and new pharmaceutical agents. It will also expose these researchers to a technique that is used extensively in chemical and pharmaceutical R&D and production, providing them with new skills of high value to future employers.

开发和优化用于药物发现和生产、聚合物合成以及高价值化学品和材料制造的新化学工艺的能力，需要了解反应机理，以及特定化学变化发生的键形成和键断裂事件的详细顺序。来自NSERC的资金将用于购买红外光谱仪，使我们的研究小组发现的新型化学转化能够实时在线监测。该仪器将提供对现有设备无法提供的反应途径细节的深入了解，使我们小组的学生和博士后研究人员能够开发下一代“绿色”，催化过程和多组分反应，用于制备增值化学产品和新药。它还将使这些研究人员接触到一种广泛用于化学和制药研发和生产的技术，为他们提供对未来雇主具有高价值的新技能。