Synthesis and physical characterization of arborescent (dendrigraft) polymers

树状聚合物的合成和物理表征

• 批准号: 121641-2009
• 负责人: Gauthier, Mario
• 金额: $ 3.64万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=475567
• 关键词: Synthesis; physical; characterization; arborescent; dendrigraft

Our research efforts focus on the synthesis and the physical characterization of graft polymers with a dendritic architecture, the arborescent polymers (AP). These macromolecules have a uniform size ranging from 2-100 nm, very high molecular weights (1E4-1E8) and branching functionalities (f=10-10000+), and a controllable chemical composition. The extensive control achieved over the structure of these materials is highly beneficial, from a fundamental viewpoint, for the establishment of structure-property correlations in branched polymers, and for their utilization in nanotechnology-related applications. Five distinct activity areas have been identified in the current proposal: 1) The solution properties of AP with polyelectrolyte side chains will be examined, focusing particularly on the formation of gels in intermediate- to low-polarity solvents, as these materials may be useful as pH-sensitive smart gels. 2) Amphiphilic AP will be studied with respect to their ability to self-assemble, either at the air-water interface or in solution, to yield superstructures (e.g. rod-like and large compound micelle assemblies) and to pattern surfaces on the manometer scale. These copolymers will also be investigated for the solubilization and release of hydrophobic compounds in aqueous environments, to serve as model systems for the controlled delivery of hydrophobic drugs. 3) New AP with enhanced biocompatibility, potentially useful as practical drug delivery devices, will be synthesized from amino acids and investigated for their solubilization properties. 4) The rheological properties of AP incorporating elastomeric chain segments will be examined to improve the understanding of the influence of branching on polymer processability. 5) A new grafting technique using "click" chemistry will be developed to allow the high yield synthesis of AP with long side chains, which have been elusive so far. The fundamental knowledge gained from the proposed work will help clarify the influence of branching on different physical properties, over a much wider range of branching functionalities than has been achieved so far using other model systems such as the star-branched polymers.

我们的研究工作主要集中在树枝状结构的接枝聚合物的合成和物理表征上。这些大分子具有2-100 nm的均匀尺寸，非常高的相对分子质量(1E4-1E8)和支化官能团(f=10-10000+)，并且化学组成可控。从根本上讲，对这些材料的结构实现广泛的控制是非常有益的，这对于建立支化聚合物的结构-性质相关性以及它们在纳米技术相关应用中的应用是非常有益的。目前的提案确定了五个不同的活性领域：1)将研究具有聚电解质侧链的AP的溶液性质，特别是在中低极性溶剂中形成凝胶，因为这些材料可能用作pH敏感的智能凝胶。2)将研究两亲性AP的自组装能力，无论是在空气-水界面上还是在溶液中，以产生超结构(例如棒状和大的复合胶束组件)，并在压力计尺度上形成表面图案。还将研究这些共聚物在水环境中对疏水化合物的增溶和释放，作为控制疏水药物输送的模型系统。3)以氨基酸为原料合成具有良好生物相容性的新型AP，并对其增溶性能进行研究。4)考察加入弹性链段的AP的流变性能，以加深对支化对聚合物加工性能影响的理解。5)将开发一种使用“点击”化学的新接枝技术，以实现高产率合成到目前为止难以捉摸的具有长侧链的AP。从拟议的工作中获得的基础知识将有助于澄清支化对不同物理性质的影响，其范围比迄今使用其他模型体系(如星形支化聚合物)实现的支化功能范围要广得多。