Beyond the genome: unravelling the intricacies of epigenetic regulation using the honey bee model

超越基因组：利用蜜蜂模型揭示表观遗传调控的复杂性

• 批准号: DP120101803
• 负责人: Em/Prof Ryszard Maleszka
• 金额: $ 19.37万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP120101803
• 关键词: Beyond; genome; unravelling; intricacies; epigenetic

Epigenetic mechanisms, such as DNA methylation, provide the interface between genome and environment. Abnormalities in epigenetic regulation lead to cancer and other diseases. The project will be using the alternative phenotypes in honeybees, fertile queens and sterile workers, to understand how dietary factors control conditional gene expression by methylation

表观遗传机制，如DNA甲基化，提供了基因组和环境之间的接口。表观遗传调控的异常会导致癌症和其他疾病。该项目将利用蜜蜂、有生育能力的蜂王和不育工蜂的不同表型，来了解饮食因素如何通过甲基化控制条件基因表达。