Epigenetic integration of genomic and environmental information in honey bees

蜜蜂基因组和环境信息的表观遗传整合

• 批准号: DP1092706
• 负责人: Em/Prof Ryszard Maleszka
• 金额: $ 40.37万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1092706
• 关键词: Epigenetic; integration; genomic; environmental; information

Environmental factors such as nutrition, drugs or childhood neglect alter gene activity without a change to the DNA code and may result in a range of conditions such as cancer, obesity and mental illness. Such epigenetic phenomena are driven by subtle and poorly understood modifications of the genome known as DNA methylation. Our aim is to study the link between DNA methylation and environmental influences. We aspire to understand how environmental signals trigger the reprogramming of transcriptional control of genetic networks that lead to contrasting phenotypic and behavioural outcomes using the honey bee model

环境因素，如营养，药物或儿童忽视改变基因活性而不改变DNA密码，并可能导致一系列疾病，如癌症，肥胖和精神疾病。这种表观遗传现象是由基因组的微妙和知之甚少的修饰驱动的，称为DNA甲基化。我们的目标是研究DNA甲基化与环境影响之间的联系。我们渴望了解环境信号如何触发基因网络的转录控制的重编程，从而导致使用蜜蜂模型的对比表型和行为结果