Epigenetic reprogramming of development by nutritional factors in honeybee

蜜蜂营养因素对发育的表观遗传重编程

• 批准号: DP160103053
• 负责人: Em/Prof Ryszard Maleszka
• 金额: $ 27.94万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160103053
• 关键词: Epigenetic; reprogramming; development; nutritional; factors

The project aims to study the mechanism by which a specialised nutrition can change or even reverse the process of adult cell fate. The project will use a previously unexplored method of nutritional reprogramming of imaginal discs in honeybees by royal jelly and identify novel components of both the genetic and epigenetic systems that are most potent as reprogramming factors. The project seeks to improve our understanding of how epigenetic remodelling of the information content of the genome contributes to conversion of cell fate in vivo and in vitro. More broadly, the project could potentially establish the honeybee imaginal discs as a model for understanding pluripotency and environmentally controlled developmental plasticity.

该项目旨在研究一种特殊营养改变甚至逆转成年细胞命运过程的机制。该项目将使用一种以前未被探索过的方法，通过蜂王浆对蜜蜂的想象盘进行营养重编程，并确定遗传和表观遗传系统中最有效的重编程因素的新成分。该项目旨在提高我们对基因组信息内容的表观遗传重塑如何有助于体内和体外细胞命运的转化的理解。更广泛地说，该项目有可能将蜜蜂的想象圆盘作为理解多能性和环境控制的发育可塑性的模型。