Organic synthesis and materials chemistry via catalytic organoborane chemistry
通过催化有机硼烷化学进行有机合成和材料化学
基本信息
- 批准号:194284-2010
- 负责人:
- 金额:$ 6.56万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2011
- 资助国家:加拿大
- 起止时间:2011-01-01 至 2012-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The ability to prepare complex organic molecules efficiently has been critical in the development of the pharmaceutical industry. Recently, similar abilities have become important in areas such as liquid crystals and organic electronics. In this case, the molecules employed must be free of isomers and other contaminants that may impact performance. Thus, state-of-the-art synthetic techniques to prepare molecules for materials applications is critical. In the case of pharmaceutical applications of organic molecules, the most urgent need is for new structures that have not been made previously and may have unique physiological activities. For these reasons, we propose to examine the synthesis of two novel classes of molecules with applications in the pharmaceutical and materials areas. Chiral 1,1-diaryl alkanes are molecules that are exceedingly difficult to make by existing routes, yet these provide novel chiral scaffolds that are of interest to the pharmaceutical industry and materials chemistry. Likewise, the chiral 1,1,1-triarylmethanes and alkanes are virtually unknown in their enantiomerically pure state. We have proposed routes to prepare these important classes of compounds based on recent chemistry from our lab. The routes provide compounds of >95% optical and isomeric purity. In our second area of research, we propose to employ frustrated Lewis pair (FLP) chemistry for the activation of alkane C-H bonds. When an acidic and a basic molecule are present in solution but are inhibited (usually by sterics) from reacting with each other they are said to be a Frustrated Lewis Pair. In this case, the molecules can cooperate to split relatively unreactive bonds such as H-H, H-Si and H-B. We plan to employ this method for the activation of C-H bonds, which is a critical goal in terms of synthesis and energy since effective C-H activation strategies could better utilize petroleum feedstocks. Initially we will use organic structures that are biased towards the desired reaction in order to demonstrate feasibility, but we plan to move toward organic molecules with less and less functionality. HQP involved in this chemistry will gain a wide range of expertise in the area of organic synthesis, catalysis, air sensitive techniques and materials chemistry.
高效制备复杂有机分子的能力一直是制药工业发展的关键。最近,类似的能力在液晶和有机电子等领域变得重要起来。在这种情况下,所使用的分子必须不含异构体和其他可能影响性能的污染物。因此,最先进的合成技术为材料应用准备分子是至关重要的。在有机分子的医药应用中,最迫切的需要是寻找以前没有制造过的、可能具有独特生理活性的新结构。出于这些原因,我们建议研究两类新型分子的合成,这些分子在制药和材料领域都有应用。手性1,1-二芳基烷烃是一类用现有路线很难合成的分子,但它们提供了制药工业和材料化学感兴趣的新型手性支架。同样,手性1,1,1-三芳基甲烷和烷烃在其对映体纯状态下几乎是未知的。根据我们实验室最近的化学知识,我们提出了制备这些重要化合物的路线。这些路线提供了95%光学纯度和同分异构体纯度的化合物。在我们的第二个研究领域,我们建议使用受挫Lewis对(FLP)化学来激活烷烃C-H键。当酸性分子和碱性分子存在于溶液中,但被阻止(通常是由立体化合物)相互反应时,它们被称为受挫的刘易斯对。在这种情况下,分子可以协同作用,分裂相对不反应的键,如H-H、H-Si和H-B。我们计划使用这种方法来激活C-H键,这是合成和能量方面的一个关键目标,因为有效的C-H激活策略可以更好地利用石油原料。最初,我们将使用偏向于所需反应的有机结构来证明可行性,但我们计划转向功能越来越少的有机分子。参与该化学的HQP将在有机合成、催化、空气敏感技术和材料化学领域获得广泛的专业知识。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Crudden, Catherine其他文献
Crudden, Catherine的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Crudden, Catherine', 18)}}的其他基金
Eliminating hazardous chemicals in key processes in the pharmaceutical sector
消除制药行业关键流程中的危险化学品
- 批准号:
430211-2012 - 财政年份:2013
- 资助金额:
$ 6.56万 - 项目类别:
Strategic Projects - Group
Organic synthesis and materials chemistry via catalytic organoborane chemistry
通过催化有机硼烷化学进行有机合成和材料化学
- 批准号:
194284-2010 - 财政年份:2013
- 资助金额:
$ 6.56万 - 项目类别:
Discovery Grants Program - Individual
NSERC CREATE Training Program in novel chiral materials: An International Effort in Research and Education
NSERC CREATE 新型手性材料培训计划:研究和教育方面的国际努力
- 批准号:
371167-2010 - 财政年份:2013
- 资助金额:
$ 6.56万 - 项目类别:
Collaborative Research and Training Experience
NSERC CREATE Training Program in novel chiral materials: An International Effort in Research and Education
NSERC CREATE 新型手性材料培训计划:研究和教育方面的国际努力
- 批准号:
371167-2010 - 财政年份:2011
- 资助金额:
$ 6.56万 - 项目类别:
Collaborative Research and Training Experience
Organic synthesis and materials chemistry via catalytic organoborane chemistry
通过催化有机硼烷化学进行有机合成和材料化学
- 批准号:
396069-2010 - 财政年份:2011
- 资助金额:
$ 6.56万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Metal-free methods for the reduction of organic compounds
减少有机化合物的无金属方法
- 批准号:
397125-2010 - 财政年份:2011
- 资助金额:
$ 6.56万 - 项目类别:
Strategic Projects - Group
Fibre optic sensor arrays for on-site monitoring of heavy metal contaminants in ground water including mercury, copper and nickel
用于现场监测地下水中汞、铜和镍等重金属污染物的光纤传感器阵列
- 批准号:
336575-2006 - 财政年份:2008
- 资助金额:
$ 6.56万 - 项目类别:
Strategic Projects - Group
Hydrogen storage with chemical hydrides: catalytic methods for regeneration
化学氢化物储氢:催化再生方法
- 批准号:
357081-2007 - 财政年份:2008
- 资助金额:
$ 6.56万 - 项目类别:
Strategic Projects Supplemental Competition
Novel chiral materials for chromatographic applications
用于色谱应用的新型手性材料
- 批准号:
364971-2008 - 财政年份:2008
- 资助金额:
$ 6.56万 - 项目类别:
Strategic Projects - Group
Organic synthesis using homogeneous and heterogeneous transition metal catalysts
使用均相和非均相过渡金属催化剂的有机合成
- 批准号:
194284-2006 - 财政年份:2008
- 资助金额:
$ 6.56万 - 项目类别:
Discovery Grants Program - Individual
相似国自然基金
胆固醇合成蛋白CYP51介导线粒体通透性转换诱发Th17/Treg细胞稳态失衡在舍格伦综合征中的作用机制研究
- 批准号:82370976
- 批准年份:2023
- 资助金额:48.00 万元
- 项目类别:面上项目
“肠—肝轴”PPARα/CYP8B1胆汁酸合成信号通路在减重手术改善糖脂代谢中的作用与机制
- 批准号:82370902
- 批准年份:2023
- 资助金额:49.00 万元
- 项目类别:面上项目
lncGEI诱导湖羊卵巢颗粒细胞E2合成的分子机制
- 批准号:32372856
- 批准年份:2023
- 资助金额:50.00 万元
- 项目类别:面上项目
脂肪酸合成通过GDF15/IRS2介导胰岛素抵抗促进血管内皮细胞活化导致脓毒症肺损伤的机制研究
- 批准号:82372203
- 批准年份:2023
- 资助金额:49.00 万元
- 项目类别:面上项目
环状RNA circ-PRKAA1调控肝癌细胞脂代谢重编程的研究
- 批准号:32000527
- 批准年份:2020
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
ALDH6A1缺损重塑糖脂代谢促进肝细胞癌发生的机制研究
- 批准号:91957109
- 批准年份:2019
- 资助金额:79.0 万元
- 项目类别:重大研究计划
新型滤波器综合技术-直接综合技术(Direct synthesis Technique)的研究及应用
- 批准号:61671111
- 批准年份:2016
- 资助金额:58.0 万元
- 项目类别:面上项目
双硅化合物反应及天然产物合成应用研究
- 批准号:21172150
- 批准年份:2011
- 资助金额:60.0 万元
- 项目类别:面上项目
新型M4受体选择性拮抗剂的研究
- 批准号:30973615
- 批准年份:2009
- 资助金额:32.0 万元
- 项目类别:面上项目
基于penicillide结构的类天然产物合成及其胆固醇酯转运蛋白抑制的研究
- 批准号:20872019
- 批准年份:2008
- 资助金额:32.0 万元
- 项目类别:面上项目
相似海外基金
CAREER: Liquid Crystal-Templated Sequential Infiltration Synthesis of Hybrid Organic/Inorganic Materials with Multidimensional Chiral Structures
职业:具有多维手性结构的有机/无机杂化材料的液晶模板连续渗透合成
- 批准号:
2337740 - 财政年份:2024
- 资助金额:
$ 6.56万 - 项目类别:
Continuing Grant
Synthesis of Azo-linked Polymers for the Development of New Organic Electrode Materials
偶氮连接聚合物的合成用于新型有机电极材料的开发
- 批准号:
557624-2021 - 财政年份:2022
- 资助金额:
$ 6.56万 - 项目类别:
Postdoctoral Fellowships
Synthesis and investigation of novel magneto-optical organic materials for applications in nonlinear optics and sensing.
用于非线性光学和传感应用的新型磁光有机材料的合成和研究。
- 批准号:
545856-2020 - 财政年份:2022
- 资助金额:
$ 6.56万 - 项目类别:
Postgraduate Scholarships - Doctoral
Development of highly active homogeneous hydrogenation catalytic systems for synthesis of novel organic materials
开发用于合成新型有机材料的高活性均相加氢催化体系
- 批准号:
21K20530 - 财政年份:2021
- 资助金额:
$ 6.56万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Design and synthesis of supramolecular organic semiconductor materials that exhibit high charge transport characteristics
具有高电荷传输特性的超分子有机半导体材料的设计与合成
- 批准号:
21K18948 - 财政年份:2021
- 资助金额:
$ 6.56万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Synthesis and investigation of novel magneto-optical organic materials for applications in nonlinear optics and sensing.
用于非线性光学和传感应用的新型磁光有机材料的合成和研究。
- 批准号:
545856-2020 - 财政年份:2021
- 资助金额:
$ 6.56万 - 项目类别:
Postgraduate Scholarships - Doctoral
Synthesis of Azo-linked Polymers for the Development of New Organic Electrode Materials
偶氮连接聚合物的合成用于新型有机电极材料的开发
- 批准号:
557624-2021 - 财政年份:2021
- 资助金额:
$ 6.56万 - 项目类别:
Postdoctoral Fellowships
Synthesis of phosphorescent organic materials
磷光有机材料的合成
- 批准号:
563931-2021 - 财政年份:2021
- 资助金额:
$ 6.56万 - 项目类别:
University Undergraduate Student Research Awards
Taming Fluorine: Metal-Organic Frameworks for the Heterogeneous Delivery of Fluorinated Building Blocks
驯服氟:用于氟化构件异质输送的金属有机框架
- 批准号:
10225599 - 财政年份:2020
- 资助金额:
$ 6.56万 - 项目类别:
Novel Reagents and Catalysts for Organic Synthesis
用于有机合成的新型试剂和催化剂
- 批准号:
10121469 - 财政年份:2020
- 资助金额:
$ 6.56万 - 项目类别: