Probing structure and causality in biochemical networks with dynamic homomeric protein complexes

用动态同聚蛋白复合物探测生化网络中的结构和因果关系

• 批准号: 194582-2010
• 负责人: Michnick, Stephen
• 金额: $ 8.23万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=476713
• 关键词: Probing; structure; causality; biochemical; networks

Problem and Hypothesis: The importance of protein-protein interactions (PPIs) to biology is reflected in the colossal efforts to study them on a large scale, including our own efforts, which resulted in a first description of a PPI network in vivo (Tarassov, et al. Science, 2008). However, like other efforts, ours captured a static map of the protein interaction network under a single condition. The general goal of studying PPI networks is to understand how proteins function as an ensemble. To achieve this, we must go beyond static maps of PPI

问题与假设：蛋白质-蛋白质相互作用（PPI）对生物学的重要性反映在大规模研究它们的巨大努力中，包括我们自己的努力，这导致了体内PPI网络的首次描述（Tarassov，et al. Science，2008）。然而，像其他努力一样，我们在单一条件下捕获了蛋白质相互作用网络的静态图。 研究PPI网络的总体目标是了解蛋白质如何作为一个整体发挥作用。为了实现这一点，我们必须超越PPI的静态地图