Structure, dynamics and causality in protein interaction networks

蛋白质相互作用网络的结构、动力学和因果关系

• 批准号: RGPIN-2015-05707
• 负责人: Michnick, Stephen
• 金额: $ 3.79万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629127
• 关键词: Structure; dynamics; causality; protein; interaction

Problem and Hypothesis: The importance of protein-protein interactions (PPIs) to biology is reflected in the enormous efforts to study them on a large scale, including our own efforts, which resulted in a first description of a PPI network in vivo (Tarassov, et al. Science, 2008). In the past funding period we have developed and validated a novel approach to study dynamics of biochemical networks and to determine protein functions, discovery of pathways and a novel mechanism of allostery. The method is based on measuring dynamics of homomeric protein complexes (HPC) on a large scale.

问题与假设：蛋白质-蛋白质相互作用（PPI）对生物学的重要性反映在大规模研究它们的巨大努力中，包括我们自己的努力，这导致了体内PPI网络的首次描述（Tarassov，et al. Science，2008）。在过去的资助期间，我们开发并验证了一种新的方法来研究生化网络的动态，并确定蛋白质功能，发现途径和变构的新机制。该方法是基于测量大规模的同聚蛋白质复合物（HPC）的动力学。