Olefin metathesis asymmetric metathesis and tandem catalysis

烯烃复分解不对称复分解和串联催化

• 批准号: 203377-2007
• 负责人: Fogg, Deryn
• 金额: $ 4.66万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=477099
• 关键词: Olefin; metathesis; asymmetric; tandem; catalysis

A major goal of our research is the design of robust, selective catalysts that promote the formation of carbon-carbon bonds. Olefin metathesis is one of the most powerful tools now in use for this purpose, as noted in the citation awarding the 2005 Nobel Prize in Chemistry to Schrock, Grubbs, and Chauvin. While the high, tunable selectivity of the Schrock catalysts is a major asset in achieving the synthesis of desired organic compounds, their high sensitivity to air and water is problematic. The Grubbs catalysts, based on the less oxophilic transition metal ruthenium, are much more easily handled, and have greatly expanded the uptake of olefin metathesis in organic synthesis. Despite this robustness, however, they are short-lived. They are also limited in terms of the ease of tuning activity and selectivity. Studying their deactivation pathways led us to develop a new family of catalyst that is longer-lived and more productive. It also offers expanded potential to define the active site at the catalyst, and thus selectivity. Combining robustness with selectivity would unite the two main streams of experimental development in olefin metathesis.

我们研究的一个主要目标是设计促进碳-碳键形成的稳健的选择性催化剂。正如2005年诺贝尔化学奖授予Schrock、Grubbs和Chauvin的引文中所指出的那样，烯烃复分解是目前用于此目的的最有力的工具之一。虽然Schrock催化剂的高的、可调的选择性是实现所需有机化合物合成的主要资产，但它们对空气和水的高敏感性是有问题的。基于亲氧性较低的过渡金属钌的Grubbs催化剂更容易处理，并且极大地扩展了烯烃复分解在有机合成中的应用。然而，尽管有这种稳健性，它们都是短暂的。它们在调整活动和选择性的容易程度方面也受到限制。研究它们的失活途径使我们开发出一种寿命更长、生产力更高的新催化剂家族。它还提供了扩大的潜力，以确定在催化剂的活性位点，从而选择性。将稳健性与选择性相结合将使烯烃复分解实验发展的两个主流结合起来。