"Z-Selective Metathesis, Alkyne Metathesis, and Deactivation in Metathesis"

“Z-选择性复分解、炔复分解和复分解失活”

• 批准号: 203377-2012
• 负责人: Fogg, Deryn
• 金额: $ 7.36万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514113
• 关键词: Selective; Metathesis; Alkyne; Deactivation

Olefin metathesis offers exceptionally powerful chemical methods for assembling carbon-carbon bonds, the frameworks of both molecules and advanced materials. It was recognized with the Nobel Prize in 2005, in part because of its enormous potential to reduce the proportion of waste generated via classical synthetic methods in chemical and pharmaceutical manufacturing. To date, however, the powerful catalysts that enable this reaction are essentially unused in industry. The problem lies in their short lifetimes, which results in uneconomic processes. We seek to understand why these catalysts are vulnerable, and how they decompose under conditions of use. Such understanding would be a powerful aid to designing next-generation, long-lived catalysts, and enabling industrial uptake.

烯烃复分解为组装碳-碳键提供了非常强大的化学方法，碳-碳键是分子和先进材料的框架。它在2005年获得了诺贝尔奖，部分原因是它具有巨大的潜力，可以减少化学和制药生产中通过经典合成方法产生的废物比例。然而，迄今为止，使该反应能够进行的强催化剂在工业中基本上未被使用。问题在于它们的寿命短，这导致不经济的过程。我们试图了解为什么这些催化剂是脆弱的，以及它们在使用条件下如何分解。这种理解将是设计下一代长寿命催化剂和实现工业化的有力帮助。