Characterization of appetite-regulating peptides in fish

鱼类食欲调节肽的表征

• 批准号: 261414-2008
• 负责人: Volkoff, Helene
• 金额: $ 2.66万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=479812
• 关键词: Characterization; appetite; regulating; peptides; fish

In vertebrates, complex hormonal networks regulate feeding, energy homeostasis and growth. Hypothalamic factors such as neuropeptide Y (NPY), orexins and cocaine and amphetamine regulated transcript (CART) ultimately control these functions by either stimulating or decreasing appetite. Other hormones, in particular gastrointestinal hormones such as amylin and cholecystokinin are released in the circulation and reach the brain where they can modulate the actions of these central factors. Environmental factors (e.g. temperature) might also affect feeding and appetite-related factors. In addition, given the link between energy reserves and reproduction, these central feeding regulators might also be influenced by reproductive events and be important regulators of reproduction.

在脊椎动物中，复杂的激素网络调节进食、能量稳态和生长。神经肽Y（NPY）、食欲素、可卡因和苯丙胺调节转录物（CART）等下丘脑因子通过刺激或降低食欲最终控制这些功能。其他激素，特别是胃肠道激素如胰淀素和胆囊收缩素在循环中释放并到达大脑，在那里它们可以调节这些中枢因子的作用。环境因素（如温度）也可能影响摄食和食欲相关因素。此外，考虑到能量储备和生殖之间的联系，这些中央摄食调节器也可能受到生殖事件的影响，并成为重要的生殖调节器。