The endocrine regulation of feeding in fish

鱼类摄食的内分泌调节

• 批准号: 261414-2013
• 负责人: Volkoff, Helene
• 金额: $ 2.91万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=667869
• 关键词: endocrine; regulation; feeding; fish

In all vertebrates, food intake regulation involves intricate networks of factors that are produced by both brain and peripheral tissues and affect brain feeding centers. Our current understanding of the regulation of feeding in fish is limited and based primarily on few species. Fish, however, are a diverse group that display large variations in feeding habits and the establishment of a general model elucidating feeding regulation in fish requires information on a wide range of species. In the past years, my research has established a comprehensive and interactive model of feeding control in fish by examining appetite related hormones in several fish. The goal of my ongoing research is to identify the molecules and physiological mechanisms regulating appetite and food intake in fish, and to examine how they are modulated by nutritional status, environmental cues and reproductive events. My studies to date have provided compelling new evidence that major interspecific differences occur in the structure, sites of production and mechanisms of action of these factors. My program is unique in that it is one of the few worldwide to use an integrative (from whole animal to genes) comparative approach to examine the endocrine regulation of feeding in both freshwater and marine fish. **This research is novel in that it will allow us to establish a general model of the endocrine regulation of feeding in fish and vertebrates and its impact on growth and reproduction. The results of these studies will provide new approaches to manage and enhance feeding and growth in fish. It will also allow us to better understand how different fish species deal with environmental stressors, a prerequisite for managing fish aquaculture. Our results will be highly beneficial to, and are likely to have impact on the local, national, and multi-national fishing and aquacultures industries. Also, given the similarities in the structure and function of appetite-related peptides between fish and mammals, our results could help build a fundamental model for feeding regulation in vertebrates and bring new insights into the mechanisms that rule diseases involving dysregulation of energy homeostasis in mammals.****************

在所有脊椎动物中，食物摄取调节涉及复杂的因素网络，这些因素由大脑和周围组织产生，并影响大脑喂养中心。我们目前对鱼类摄食规则的了解是有限的，主要是基于少数几个物种。然而，鱼类是一个多样化的群体，在摄食习性上表现出很大的差异，建立一个阐明鱼类摄食调节的一般模型需要关于广泛物种的信息。在过去的几年里，我的研究通过检测几种鱼类的食欲相关激素，建立了一个全面的、交互的鱼类摄食控制模型。我正在进行的研究的目标是确定调节鱼类食欲和食物摄入量的分子和生理机制，并研究它们是如何受到营养状况、环境线索和生殖事件的调节的。到目前为止，我的研究提供了令人信服的新证据，表明这些因素的结构、产生地点和作用机制在种间存在重大差异。我的项目的独特之处在于，它是世界上少数几个使用综合(从整个动物到基因)比较方法来研究淡水和海水鱼类摄食的内分泌调节的项目之一。**这项研究是新颖的，因为它将使我们能够建立一个关于鱼类和脊椎动物摄食的内分泌调节及其对生长和繁殖的影响的一般模型。这些研究的结果将为管理和加强鱼类的摄食和生长提供新的方法。它还将使我们更好地了解不同的鱼类物种如何应对环境压力，这是管理鱼类水产养殖的先决条件。我们的结果将对地方、国家和跨国渔业和水产养殖业非常有利，并可能产生影响。此外，考虑到鱼类和哺乳动物之间食欲相关肽的结构和功能上的相似之处，我们的结果可能有助于建立脊椎动物摄食调节的基本模型，并为哺乳动物能量平衡失调等疾病的统治机制带来新的见解。