The endocrine regulation of feeding in fish

鱼类摄食的内分泌调节

• 批准号: 261414-2013
• 负责人: Volkoff, Helene
• 金额: $ 2.91万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=547749
• 关键词: endocrine; regulation; feeding; fish

In all vertebrates, food intake regulation involves intricate networks of factors that are produced by both brain and peripheral tissues and affect brain feeding centers. Our current understanding of the regulation of feeding in fish is limited and based primarily on few species. Fish, however, are a diverse group that display large variations in feeding habits and the establishment of a general model elucidating feeding regulation in fish requires information on a wide range of species. In the past years, my research has established a comprehensive and interactive model of feeding control in fish by examining appetite related hormones in several fish. The goal of my ongoing research is to identify the molecules and physiological mechanisms regulating appetite and food intake in fish, and to examine how they are modulated by nutritional status, environmental cues and reproductive events. My studies to date have provided compelling new evidence that major interspecific differences occur in the structure, sites of production and mechanisms of action of these factors. My program is unique in that it is one of the few worldwide to use an integrative (from whole animal to genes) comparative approach to examine the endocrine regulation of feeding in both freshwater and marine fish.

在所有脊椎动物中，食物摄入调节涉及由大脑和外周组织产生的复杂因素网络，并影响大脑摄食中心。我们目前对鱼类摄食调节的理解是有限的，主要基于少数几个物种。然而，鱼类是一个多样化的群体，其摄食习惯差异很大，建立一个阐明鱼类摄食调节的一般模型需要广泛的物种信息。在过去的几年里，我的研究已经建立了一个全面的和互动的摄食控制模型，通过检查几种鱼类的食欲相关激素。我正在进行的研究的目标是确定调节鱼类食欲和食物摄入的分子和生理机制，并研究它们如何受到营养状况，环境线索和生殖事件的调节。迄今为止，我的研究提供了令人信服的新证据表明，主要种间差异发生在这些因素的结构，生产地点和作用机制。我的计划是独一无二的，因为它是世界上少数几个使用综合（从整个动物到基因）比较方法来研究淡水鱼和海水鱼喂养的内分泌调节的项目之一。