The influence of ubiquitous environmental contaminents on beta cell survival and function
普遍存在的环境污染物对 β 细胞存活和功能的影响
基本信息
- 批准号:288336-2009
- 负责人:
- 金额:$ 2.33万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2011
- 资助国家:加拿大
- 起止时间:2011-01-01 至 2012-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Concerns about the adverse health effects associated with exposure to environmental contaminants have been increasing globally. In recent years it has been suggested that the epidemic of Type 2 is due to lifestyle changes associated with industrialization and a more "modern" society. However industrialization is also associated with an increased exposure to synthetic chemicals associated with consumer goods, industrial and agricultural practices. It has therefore been suggested that chemicals in the environment may contribute to the development of diabetes. It is true that elevated levels of some environmental chemicals have been measured in people with diabetes but this does not prove that the chemical exposure causes the disease. The goal of this project is to determine whether chemicals that are commonly found in our environment can affect the function of the pancreas and therefore be related to the development of type 2 diabetes. This project will use insulin secreting pancreatic beta cells to determine if a wide variety of commonly encountered chemicals present in the environment can impair the normal function of these cells and/or cause the beta cells to die. I will also investigate whether the developing pancreas (fetus or newborn) is more susceptible to these chemical insults than the adult pancreas. We will also determine whether these chemicals are all acting through a common pathway to cause damage to the pancreas and attempt to find ways to prevent or reduce the effects of this exposure. The results from this study will determine whether toxic chemicals in the environment are capable of causing metabolic endocrine disruption in animal and human populations. These results will also be important to determine whether chemicals in the environment are contributing to the increased rates of type 2 diabetes around the world.
在全球范围内,人们越来越关注与接触环境污染物有关的不良健康影响。 近年来,有人认为2型糖尿病的流行是由于工业化和更“现代”的社会所带来的生活方式的改变。 然而,工业化也与消费品、工业和农业做法中合成化学品的接触增加有关。 因此,有人认为,环境中的化学品可能有助于糖尿病的发展。 确实,在糖尿病患者中测量到了一些环境化学物质的水平升高,但这并不能证明化学物质暴露会导致疾病。 该项目的目标是确定我们环境中常见的化学物质是否会影响胰腺功能,从而与2型糖尿病的发展有关。 该项目将使用分泌胰岛素的胰腺β细胞来确定环境中存在的各种常见化学物质是否会损害这些细胞的正常功能和/或导致β细胞死亡。 我还将研究发育中的胰腺(胎儿或新生儿)是否比成人胰腺更容易受到这些化学损伤。 我们还将确定这些化学物质是否都通过共同的途径对胰腺造成损害,并试图找到预防或减少这种暴露影响的方法。 这项研究的结果将确定环境中的有毒化学品是否能够引起动物和人类群体的代谢内分泌干扰。 这些结果对于确定环境中的化学物质是否导致世界各地2型糖尿病发病率的增加也很重要。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Holloway, Alison其他文献
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{{ truncateString('Holloway, Alison', 18)}}的其他基金
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色氨酸代谢:内分泌干扰的新靶点
- 批准号:
RGPIN-2020-06358 - 财政年份:2022
- 资助金额:
$ 2.33万 - 项目类别:
Discovery Grants Program - Individual
Tryptophan metabolism: a novel target for endocrine disruption
色氨酸代谢:内分泌干扰的新靶点
- 批准号:
RGPIN-2020-06358 - 财政年份:2021
- 资助金额:
$ 2.33万 - 项目类别:
Discovery Grants Program - Individual
Tryptophan metabolism: a novel target for endocrine disruption
色氨酸代谢:内分泌干扰的新靶点
- 批准号:
RGPIN-2020-06358 - 财政年份:2020
- 资助金额:
$ 2.33万 - 项目类别:
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Peripheral serotonergic signaling: A novel target for endocrine disruption
外周血清素信号传导:内分泌干扰的新靶点
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RGPIN-2015-05061 - 财政年份:2019
- 资助金额:
$ 2.33万 - 项目类别:
Discovery Grants Program - Individual
Peripheral serotonergic signaling: A novel target for endocrine disruption
外周血清素信号传导:内分泌干扰的新靶点
- 批准号:
RGPIN-2015-05061 - 财政年份:2018
- 资助金额:
$ 2.33万 - 项目类别:
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Feasibility of including reproductive outcomes in oil sands wildlife biomonitoring programs
将生殖结果纳入油砂野生动物生物监测计划的可行性
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519922-2017 - 财政年份:2017
- 资助金额:
$ 2.33万 - 项目类别:
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Peripheral serotonergic signaling: A novel target for endocrine disruption
外周血清素信号传导:内分泌干扰的新靶点
- 批准号:
RGPIN-2015-05061 - 财政年份:2017
- 资助金额:
$ 2.33万 - 项目类别:
Discovery Grants Program - Individual
Peripheral serotonergic signaling: A novel target for endocrine disruption
外周血清素信号传导:内分泌干扰的新靶点
- 批准号:
RGPIN-2015-05061 - 财政年份:2016
- 资助金额:
$ 2.33万 - 项目类别:
Discovery Grants Program - Individual
Peripheral serotonergic signaling: A novel target for endocrine disruption
外周血清素信号传导:内分泌干扰的新靶点
- 批准号:
RGPIN-2015-05061 - 财政年份:2015
- 资助金额:
$ 2.33万 - 项目类别:
Discovery Grants Program - Individual
The influence of ubiquitous environmental contaminents on beta cell survival and function
普遍存在的环境污染物对 β 细胞存活和功能的影响
- 批准号:
288336-2009 - 财政年份:2014
- 资助金额:
$ 2.33万 - 项目类别:
Discovery Grants Program - Individual
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288336-2009 - 财政年份:2010
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Discovery Grants Program - Individual
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