Synthesis of nitrogen-containing molecules using bifunctional reagents and organocatalysts

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Over 90% of the compounds manufactured and tested by pharmaceutical companies have at least one nitrogen atom in their structure, and approximately one reaction out of six performed in the pharmaceutical industry involves the formation of a carbon-nitrogen bond. As such, new methods to access nitrogen containing molecules can help in drug discovery by providing shorter and more efficient access to these compounds. Many fine and bulk chemicals also incorporate nitrogen atoms. Surprisingly, the conversion of cheap petrochemicals or easily accessible starting materials (alkenes, alkynes and arenes) into nitrogen-containing molecules currently requires several steps and more cost-effective, efficient processes are possible and needed. Such direct processes stand out as highly desirable but remain rarely used in industry and academia, despite well-recognized potential and intense research efforts worldwide. This proposal will provide such new technology targeting common structural elements founds in pharmaceuticals and bioactive natural products.