Microwave Reactor and Raman Spectrometer for In Situ Reaction Analysis

用于原位反应分析的微波反应器和拉曼光谱仪

• 批准号: RTI-2020-00833
• 负责人: Beauchemin, André
• 金额: $ 10.29万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693552
• 关键词: Microwave; Reactor; Raman; Spectrometer; Situ

The requested microwave reactor with Raman spectrometer and autosampler will be critical piece of infrastructure to execute and analyze high-temperature and high-pressure reactions. This unique combination of instruments just became commercially available in 2019 and provides a new, unique tool to perform in-line monitoring of microwave reactions. By allowing reaction kinetics and the observation of key reaction intermediates, it will provide a crucial new tool to facilitate the determination of reaction mechanisms, a key parameter for the development of new reactivity and optimization of novel chemical transformations. This equipment will provide measurement capabilities unique in Canada and will enable researchers to make advances in synthetic chemistry that otherwise would not be accessible to them. ******Reactions in the applicants' laboratories are routinely performed under inert atmosphere to eliminate exogenous oxygen, moisture or to prevent volatile reactants from escaping. However, the study of these reactions is obfuscated by the lack of available methods for in situ analysis. Other methods to perform reaction monitoring, including NMR and ReactIR are unfortunately not suitable to the study of high-temperature and high-pressure reactions, and also cannot be used to analyze reactions of sensitive organometallic catalysts. Consequently, the study of newly discovered reactions at the molecular level can be exceptionally challenging or impossible. The impact of these limitations can lead to: (i) the development of less efficacious catalytic systems, (ii) the inability to draft and validate accurate hypotheses based on reaction outcomes, and (iii) delays that negatively impact publication in scientific journals, collaborations with academic and industrial partners and fundamental advances in the field.******In contrast, acquisition of this instrument will have immediate impact on the applicants' ability to analyze high-temperature and high-pressure reactions. Due to the combination of Anton-Paar's expertise in Raman spectroscopy and microwave reactors, Raman measurements can now be obtained from outside the sealed tube via a fibre optic probe inserted into the microwave reaction cavity. The microwave will be equipped with an auto-sampler to make reaction screening autonomous and facilitate HQP training. Therefore, productivity would be greatly enhanced as reactions could be run on a nearly 24/7 basis. This instrument will provide a new resource to the ca. 60 HQP that use microwave reactors, a new capability to perform reaction kinetics in batch for others, and the HQP training plan involves a small, diverse team to facilitate training, reaction setup and analysis. This will facilitate adoption of a technology streamlining reaction discovery and optimization within uOttawa, and enable outside users to access this new capability.*****

所要求的带拉曼光谱仪和自动进样器的微波反应器将是执行和分析高温高压反应的关键基础设施。这种独特的仪器组合在2019年刚刚上市，为进行微波反应的在线监测提供了一种新的独特工具。通过允许反应动力学和关键反应中间体的观察，它将为促进反应机理的确定提供重要的新工具，为开发新的反应性和优化新的化学转化提供关键参数。该设备将提供加拿大独一无二的测量能力，并将使研究人员能够在合成化学方面取得进展，否则他们将无法获得这些进展。******申请人实验室中的反应通常在惰性气氛下进行，以消除外源氧气，水分或防止挥发性反应物逸出。然而，由于缺乏可用的原位分析方法，对这些反应的研究很混乱。其他进行反应监测的方法，包括NMR和ReactIR，不幸的是不适合研究高温高压反应，也不能用于分析敏感的有机金属催化剂的反应。因此，在分子水平上研究新发现的反应是非常具有挑战性的，甚至是不可能的。这些限制的影响可能导致：(i)开发效率较低的催化系统，（ii）无法根据反应结果起草和验证准确的假设，以及（iii）延迟在科学期刊上发表负面影响，与学术和工业伙伴的合作以及该领域的基础进展。******相比之下，获得该仪器将对申请人分析高温高压反应的能力产生直接影响。由于Anton-Paar在拉曼光谱和微波反应器方面的专业知识的结合，现在可以通过插入微波反应腔的光纤探针从密封管外部获得拉曼测量。微波将配备自动取样器，使反应筛选自动化，并促进HQP培训。因此，生产力将大大提高，因为反应可以在几乎24/7的基础上运行。该仪器将为大约60个使用微波反应器的HQP提供新的资源，为其他HQP提供批量执行反应动力学的新能力，HQP培训计划包括一个小的，多样化的团队，以促进培训，反应设置和分析。这将促进uOttawa内部简化反应发现和优化技术的采用，并使外部用户能够访问这项新功能。*****