Development and evaluation of novel bone anchors and "smart" adaptive implants for the treatment of the bone deficient skeleton

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Loss of the biomechanical integrity of the skeleton due to fracture or loss of bone tissue often leads to premature disability and leaves the patient with a reduced quality of life. The economic burden on the health care system of skeletal conditions such as osteoporosis-related fractures, osteolytic bone loss and other bone defects related to trauma, bone tumors and surgical resections is enormous. Despite considerable research efforts in implant design, augmentation methods and regenerative medicine approaches, the surgical treatment of the bone deficient skeleton remains challenging with unsatisfactionary clinical outcomes.