Regulation of Angiogenesis by fibulin-5

fibulin-5 对血管生成的调节

• 批准号: 355710-2008
• 负责人: Davis, Elaine
• 金额: $ 2.55万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=482825
• 关键词: Regulation; Angiogenesis; fibulin

Human skin is one of the largest and most complex organ systems in the body forming a functional barrier between the external environment and the internal structures. Within the skin, a delicate compositional and organizational balance of extracellular matrix (ECM) proteins is required for proper function. In addition to ECM proteins, cutaneous blood vessels are also critical for the development and function of skin by providing an essential supply of oxygen and nutrients. Recently, we have discovered that mice lacking the protein, fibulin-5, have a significant increase in the number of cutaneous blood vessels. This observation led us to the hypothesis that fibulin-5 can influence blood vessels formation (angiogenesis) in a negative manner. The short-term goal of our research program, therefore, is to understand the basic biological mechanism of fibulin-5 in the regulation of angiogenesis. In the long-term, our research program is focused on determining how ECM proteins direct and control blood vessel development and stability.

人体皮肤是人体内最大、最复杂的器官系统之一，在外部环境和内部结构之间形成功能屏障。 在皮肤内，细胞外基质（ECM）蛋白质的微妙组成和组织平衡是正常功能所必需的。 除了ECM蛋白，皮肤血管通过提供氧气和营养物质的基本供应对皮肤的发育和功能也至关重要。 最近，我们发现缺乏蛋白质fibulin-5的小鼠皮肤血管数量显著增加。这一观察结果使我们假设，fibulin-5可以以负面方式影响血管形成（血管生成）。 因此，我们研究计划的短期目标是了解fibulin-5在血管生成调节中的基本生物学机制。 从长远来看，我们的研究计划侧重于确定ECM蛋白如何指导和控制血管发育和稳定性。