The rat water and electrolyte balance: experimental and computational simulation study

大鼠水电解质平衡：实验和计算模拟研究

• 批准号: 355926-2011
• 负责人: Mouginot, Didier
• 金额: $ 1.75万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=482944
• 关键词: rat; water; electrolyte; balance; experimental

Ionic composition and volume of the body fluid compartments, like plasma are essential for maintaining the integrity of several vital biological parameters like blood pressure. The physiological function that controls the apparent stability of the ionic composition and osmolality of the fluid compartments is known under hydromineral homeostasis. This specific function groups together multiple and complex regulatory systems that constantly adjust the body hydromineral balance via renal excretion, as well as fluid and electrolyte ingestion. However, the study and thus, the understanding, of the dynamics and interactions of the complex systems underlying the hydromineral homeostasis would be difficult to perform experimentally.

体液隔室（如血浆）的离子组成和体积对于维持几个重要生物参数（如血压）的完整性至关重要。控制离子组成的表观稳定性和液体隔室的渗透压的生理功能在水矿物体内平衡下是已知的。这种特殊的功能将多个复杂的调节系统组合在一起，这些调节系统通过肾脏排泄以及液体和电解质摄入不断调节身体水矿物平衡。然而，研究和理解，复杂系统的动力学和相互作用的基础上的水矿物稳态将难以进行实验。