New avenues in bioinorganic chemistry: catalysis in vivo, and bimetallic systems for small-molecule transformations

生物无机化学的新途径：体内催化和小分子转化的双金属系统

• 批准号: 371598-2009
• 负责人: Storr, Timothy
• 金额: $ 3.28万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=483643
• 关键词: New; avenues; bioinorganic; chemistry; catalysis

This interdisciplinary inorganic chemistry research program is directed in two different areas: (1) the use of endogenous catalysts in the brain to promote the synthesis of diagnostic and therapeutic molecules for treating neurodegenerative disease and (2) the development of catalysts containing two metal centers in close proximity to promote selective small-molecule oxidative transformations. Essential to this research is the study of how metal ions either in vivo or in designed coordination environments interact with substrates and perform in catalytic applications.

这个跨学科的无机化学研究计划针对两个不同的领域：（1）在大脑中使用内源性催化剂，以促进治疗神经退行性疾病的诊断和治疗分子的合成;（2）开发含有两个金属中心的催化剂，以促进选择性小分子氧化转化。这项研究的关键是研究金属离子在体内或设计的配位环境中如何与底物相互作用并在催化应用中发挥作用。