Development of natural and semi-synthetic synergists for insecticide and pharmaceutical use

天然和半合成杀虫剂和药物增效剂的开发

• 批准号: 417954-2011
• 负责人: Durst, Tony
• 金额: $ 2.91万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=494879
• 关键词: Development; natural; semi; synthetic; synergists

The goal of this project is to develop a new insecticide synergist that is more potent than the currently used piperonyl butoxide (PBO) by generating and evaluating derivatives readily obtainable from the natural products dillapiol and seesamol. If successful, this will reduce substantially the quantities of insecticide needed to control insect pests. These synergists inhibit the cytochrome P450 enzymes which insects use to metabolize and eliminate the insecticide. Preliminary results have yielded derivatives that are 30 -100 times more potent than PBO. The best inhibitors, identified by in vitro assays, will be tested by combining with both natural insecticides such as the pyrethrins and synthetic pesticides and tested to determine if the mixtures are an effective method for controlling a number of commercially important insect pests.

该项目的目标是开发一种新的杀虫剂，比目前使用的胡椒基丁醚（PBO）更有效，通过产生和评估衍生物容易获得的天然产品dillapiol和seesophosphate。 如果成功，这将大大减少控制害虫所需的杀虫剂数量。这些增效剂抑制昆虫用来代谢和消除杀虫剂的细胞色素P450酶。初步结果已经产生了比PBO有效30 - 100倍的衍生物。通过体外试验确定的最佳抑制剂将通过与天然杀虫剂（如除虫菊酯）和合成杀虫剂结合进行测试，并进行测试以确定混合物是否是控制许多商业上重要的昆虫害虫的有效方法。