Extraction of artemisinin from Artemisia annua L

从青蒿中提取青蒿素

• 批准号: 418879-2011
• 负责人: ArandaSaldana, Marleny
• 金额: $ 1.82万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=495101
• 关键词: Extraction; artemisinin; Artemisia; annua

Malaria has caused many deaths worldwide, mainly in Africa. Most people affected by this disease are children under five years of age. Several treatments have been proposed to combat this disease but, among the compounds studied to date, artemisinin has shown potential due to its therapeutic effect. Different solvent extraction methodologies have been used to isolate artemisinin from natural sources such as Artemisia annua L leaves. However, the amount and purity of the artimisinin obtained are still a challenge. The main objective of this project is to use supercritical fluid (SCF) extraction, an environmentally-friendly "green" technology, to extract artemisinin from Artemisia annua L leaves provided by Bio-Share International Ltd. SCF extraction using carbon dioxide as the solvent allows easy separation of the solvent from the extracted arteminisin, leaving a product that is easy to isolate and characterize. Results from SCF extraction (in terms of yield and product quality) will be compared to conventional solvent extraction. A high yield of pure artimisinin will allow commercialization of artimisinin produced in Canada and will strengthen Canada's agricultural sector. Successful extraction and commercialization of artimisinin also has a social benefit of potentially providing an affordable treatment for malaria, a widespread disease affecting the third world.

疟疾在全世界造成许多人死亡，主要是在非洲。受这种疾病影响的大多数人是五岁以下的儿童。已经提出了几种治疗方法来对抗这种疾病，但在迄今为止研究的化合物中，青蒿素因其治疗效果而显示出潜力。不同的溶剂提取方法已被用于从天然来源如黄花蒿叶中分离青蒿素。然而，所获得的青蒿素的量和纯度仍然是一个挑战。本项目的主要目的是利用超临界流体萃取技术，一种环保的“绿色”技术，从Bio-Share International Ltd.提供的青蒿叶中提取青蒿素。将超临界流体萃取的结果（在产率和产品质量方面）与常规溶剂萃取进行比较。高产的纯青蒿素将使加拿大生产的青蒿素商业化，并将加强加拿大的农业部门。青蒿素的成功提取和商业化还具有潜在地为疟疾提供负担得起的治疗的社会效益，疟疾是一种影响第三世界的广泛疾病。