Biological Irradiator

生物辐照器

• 批准号: 422530-2012
• 负责人: Treanor, Bebhinn
• 金额: $ 10.35万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=495811
• 关键词: Biological; Irradiator

X-ray radiation is a common medical technique used to diagnose and treat many injuries and diseases. It is equally an important technique in scientific research. A biological X-ray irradiator is vital to the research of several groups in the Department of Biological Sciences at University of Toronto Scarborough, spanning diverse fields including ecology and evolutionary biology, neuroscience, cell biology, microbiology, and immunology. For the expanding 'Cells and Infection' research cluster, a biological irradiator will allow these researchers to expand the scope of their research as it will open the opportunity to utilize one of the most powerful techniques in the immunologist's toolbox and which has been a cornerstone of experimental studies in cellular and humoral immunity for decades, bone marrow transplantation. Moreover, this technique will allow researchers to genetically define the important cellular components crucial for the functioning of the immune system. This research will address questions related to B cell activation, a critical component of the adaptive immune system responsible for the production of antibodies, as well as the cell biology of phagocytosis, the process by which cells of the immune system take up and destroy pathogens. In addition, this equipment is vital to research projects utilizing primary neurons in order to address questions related to the mechanisms of cell death in ischemic diseases such as stroke and heart attack. Finally, the equipment requested will facilitate evolutionary ecology work studying behavioural, life history, and morphological traits related to reproductive success. Thus, the biological irradiator requested here will impact on the research of diverse fields in the biological sciences, which together address important questions in medical and health sciences and ecology.

X射线辐射是一种常见的医疗技术，用于诊断和治疗许多损伤和疾病。它也是科学研究中的一项重要技术。生物X射线辐射器对于多伦多斯卡伯勒大学生物科学系的多个研究小组的研究至关重要，这些研究小组涵盖生态学和进化生物学、神经科学、细胞生物学、微生物学和免疫学等多个领域。对于不断扩大的“细胞和感染”研究集群，生物辐照器将使这些研究人员能够扩大他们的研究范围，因为它将有机会利用免疫学家工具箱中最强大的技术之一，并且几十年来一直是细胞和体液免疫实验研究的基石，骨髓移植。此外，这项技术将使研究人员能够从基因上定义对免疫系统功能至关重要的重要细胞成分。这项研究将解决与B细胞活化有关的问题，B细胞活化是适应性免疫系统的一个关键组成部分，负责产生抗体，以及吞噬作用的细胞生物学，免疫系统细胞吸收和破坏病原体的过程。此外，该设备对于利用初级神经元的研究项目至关重要，以解决与缺血性疾病（如中风和心脏病发作）中细胞死亡机制相关的问题。最后，所要求的设备将有助于研究与繁殖成功有关的行为、生活史和形态特征的进化生态学工作。因此，这里要求的生物辐照器将影响生物科学中不同领域的研究，这些领域共同解决医学和健康科学以及生态学中的重要问题。