The X-Rad SmART+ Biological Irradiator for Pre-Clinical Oncology Research

7.项目摘要/摘要。 这个应用程序为最先进的共享资源X-Rad小动物辐射申请资金 治疗(SMART)生物辐射仪(精密X射线，北布兰福德，康涅狄格州)，以取代我们现有的X- RAD 225Cx生物辐射器(也由Precision X-Ray制造)。根据Precision X-Ray的“End- 生活中的《信》，…EOL(生命周期终止)是指2020年12月31日，在此日期之后，我们将无法 根据新的支持协议为单位提供服务和/或提供服务。(精密X射线随后同意 为我们的X-Rad 225Cx生物辐射器提供服务支持，不包括X射线管和发电机 至2021年12月31日。)当然，放射治疗(RT)仍然是最广泛使用和 有效的癌症治疗方式，纪念斯隆·凯特琳癌症中心(MSK)长期以来 被公认为RT研究、开发和患者护理方面的全球领导者。由于它安装在 2014年，我们大量使用的X-Rad 225Cx生物辐射器为这一遗产做出了巨大贡献，提供 为美国国立卫生研究院资助的基础和翻译调查提供宝贵的技术能力 实验性啮齿动物模型中正常组织和肿瘤对治疗性外照射的影响。临床- 分级外放射治疗现在是临床前肿瘤学研究的重要组成部分。 计划在MSK。所要求的仪器，最先进的X-Rad SMART，是一种图像制导， 等中心(360旋转，具有电弧治疗功能)，自屏蔽研究型辐照器，结合了高 分辨率(100m)锥束CT成像系统和高剂量率(高达约5/分钟) 将治疗性X射线源整合到一个由计算机控制的集成平台中。它包括种类繁多的 固定场准直器.圆形(直径0.5至25 mm)、正方形(3 x 3至40 x 40 mm)和矩形(8 x 12至30 x 40 mm)-外加一个可调整的视场整形准直器。X-Rad SMART还包括智能- 基于蒙特卡罗模型的临床级治疗计划系统。 与其前身X-Rad 225Cx类似，X-Rad智能生物辐照仪是一种复杂的仪器 需要制造商及时提供的服务和应用程序支持以及定期软件更新，以 确保尖端的、经常是时间敏感的实验工作所要求的可靠性能。如果没有 这样的支持，重要的资助实验将会非常严重地受到损害，或者干脆放弃。 因此，X-Rad智能生物辐射器对于许多高效、 美国国立卫生研究院资助的MSK临床前肿瘤学研究项目。

7. Project Summary/Abstract. This application requests funds for a state-of-the-art shared resource, the X-Rad Small-Animal Radiation Therapy (SmART)+ Biological Irradiator (Precision X-Ray, North Branford, CT), to replace our existing X- Rad 225Cx Biological Irradiator (also manufactured by Precision X-Ray). Pursuant to Precision X-Ray’s “end- of-life” letter, “…the EOL (End Of Life) is the date - December 31st, 2020 - after which we will no longer be able to service and/or cover the unit under a new support agreement.” (Precision X-Ray subsequently agreed to provide service support for our X-Rad 225Cx Biological Irradiator exclusive of the X-ray tube and generator through December 31st, 2021.) Radiation therapy (RT) remains, of course, one of the most widely used and effective cancer treatment modalities, and Memorial Sloan Kettering Cancer Center (MSK) has long been recognized as a worldwide leader in research, development, and patient care in RT. Since its installation in 2014, our heavily used X-Rad 225Cx Biological Irradiator has contributed enormously to this legacy, providing invaluable technical capabilities for NIH-funded basic and translational investigations on the response of normal tissues and tumors in experimental rodent models to therapeutic external-beam irradiation. Clinical- grade external-beam radiation therapy is now an essential component of the pre-clinical oncology research program at MSK. The instrument requested, the state-of-the-art X-Rad SmART+, is an image-guided, isocentric (360 rotation, with arc therapy capability), self-shielded research irradiator combining a high- resolution (100 m) cone-beam CT imaging system and a high-dose rate (up to approximately 5 Gy/min) therapeutic X-ray source into a single integrated, computer-controlled platform. It includes a wide variety of fixed-field collimators – circular (0.5 to 25 mm in diameter), square (3 x 3 to 40 x 40 mm), and rectangular (8 x 12 to 30 x 40 mm) – plus an adaptable field-shaping collimator. The X-Rad SmART+ also includes SmART - ATP (Advanced Treatment Planning), a clinical-grade Monte Carlo modeling-based treatment planning system. Similar to its predecessor, the X-Rad 225Cx, the X-Rad SmART+ Biological Irradiator is a complex instrument requiring timely manufacturer-provided service and applications support and periodic software updates to ensure the reliable performance which cutting-edge, often time-sensitive experimental work demands. Without such support, important funded experiments would be very seriously compromised or abandoned altogether. The X-Rad SmART+ Biological Irradiator is thus essential for the ongoing work of numerous highly productive, NIH-funded projects in MSK’s pre-clinical oncology research program.