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Coevolutionary mechanisms within vector/pathogen complexes

载体/病原体复合体内的共同进化机制

基本信息

批准号：
355850-2008
负责人：
Kyle, Christopher
金额：
$ 1.31万
依托单位：
Trent University
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2012
资助国家：
加拿大
起止时间：
2012-01-01 至 2013-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=497511
关键词：
Coevolutionary mechanisms within vector pathogen

项目摘要

In Canada, significant northward range expansions of several wildlife diseases increasingly threaten the health of humans, domestic animals, and native species. The monetary costs of managing an increasing array of wildlife disease is untenable for many natural resource agencies; as such, there is a significant need to understand the mechanisms of disease maintenance and spread to maximize available resources. Specifically, I will investigate coevolutionary mechanisms within vector/pathogen complexes using the raccoon rabies virus, and its primary vector, raccoons, as a model system. Conventional belief suggests that rabies is a lethal disease with no potential for evolution within its hosts. Disease challenge and vaccination experiments, however, indicate that variability exists in the immune response of raccoons to this virus. I will explore the ability of raccoons and raccoon populations to adapt to raccoon rabies by profiling major histocompatiblity complex (Mhc) genes that are intimately associated with the initiation of an immune response. My research will contribute to our understanding of the spatial organization of disease resistance and susceptibility, enhance our knowledge of coevolutionary mechanisms associated with disease spread and maintenance, and help refine current disease control strategies.

在加拿大，一些野生动物疾病向北扩展的范围日益威胁着人类、家畜和本地物种的健康。管理越来越多的野生动物疾病的货币成本是许多自然资源机构无法承受的；因此，有必要了解疾病维持和传播的机制，以最大限度地利用现有资源。具体来说，我将以浣熊狂犬病病毒及其主要载体浣熊为模型系统，研究媒介/病原体复合体内的协同进化机制。传统观念认为，狂犬病是一种致命疾病，在宿主体内没有进化的可能。然而，疾病挑战和疫苗接种实验表明，浣熊对这种病毒的免疫反应存在变异性。我将通过分析与免疫反应启动密切相关的主要组织相容性复合体（Mhc）基因，探索浣熊和浣熊种群适应浣熊狂犬病的能力。我的研究将有助于我们对疾病抗性和易感性的空间组织的理解，增强我们对疾病传播和维持相关的共同进化机制的认识，并有助于完善当前的疾病控制策略。